Proton MRI of MSK Disorders

NCT07845708 — Recruiting, 100 participants, Laura Walkup

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Ultra-Short Echo Time 1H MRI in Individuals With Thoracic Musculoskeletal Disorders

Registry	NCT07845708
Status	Recruiting
Study type	Observational
Enrollment	100 (Estimated)
Sponsor	Laura Walkup (Other)
Conditions	Muskuloskeletal Diseases, Healthy, Respiratory
Interventions	MRI (Diagnostic test)
Dates	start 2025-06-17, primary completion 2030-06-01 (estimated), completion 2030-06-01 (estimated), first posted 2026-09-29, last updated 2026-10-16
Locations	1 site in United States

-Summary

In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. The investigators will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. The investigators also want to collect images and health information about lungs that are healthy or those in people with different kinds of lung, muscular, and bone diseases. This collection will help us in the future to better understand lung variations in health and disease.

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+Arms and interventions

MRI (Diagnostic test): This intervention uses specialized MRI sequences, UTE and bSSFP, alongside traditional MRI to capture high-resolution images of lung structure and function. These sequences are optimized for imaging pulmonary tissues and airspaces, which is not typical in standard clinical MRI protocols. The study focuses on both healthy participants and those with lung, muscular, and bone diseases to evaluate variations in lung imaging.

+Outcome measures

Primary outcomes

Develop, optimize, and validate of 1H MRI sequences for assessment of lung structure and function [Through study completion, an average of 5 years]: Structural 1H MRI parameters such as relative 1H signal intensity and radiologists interpretation will be compared to retrospective clinical images to determine viability of 1H MRI to assess lung disease.
Generate preliminary bSSFP UTE 1H MRI data in healthy individuals and individuals with thoracic musculoskeletal disorders. [Through study completion, an average of 5 years]: Free-breathing bSSFP UTE 1H MRI images will be compared to other conventional structural 1H MRI techniques and aspects like relative 1H signal between images will be compared.

+Eligibility

Sex: All, ages: 5 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Age ≥ 5 years

Exclusion Criteria:

* History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject.
* Standard MRI exclusion criteria as set forth by the CCHMC Radiology Department and IRC.
* Pregnancy

+Locations (1)

Facility	City	Country	Status
Cincinnati Children's Hospital Medical Center	Cincinnati, Ohio	United States	Recruiting

+Investigators

Laura Walkup, PhD, Principal investigator, Children's Hospital Medical Center, Cincinnati

My Notes

Public

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