Corneal Topography and High Order Aberrations in Regular Contraceptive Pills

NCT07693673 — Completed, 40 participants, Elshimaa A.Mateen

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Corneal Topography and High Order Aberrations in Women on Regular Contraceptive Pills

RegistryNCT07693673
StatusCompleted
Study typeObservational
Enrollment40 (Actual)
SponsorElshimaa A.Mateen (Other)
ConditionsCornea, Refraction Error
InterventionsHormonal Contraception, Combined Oral Contraceptive (COC) (Other, drug)
Datesstart 2024-10-01, primary completion 2026-01-30, completion 2026-03-30, first posted 2026-07-09, last updated 2026-07-09
Locations1 site in Egypt

Related Papers Related Patents Related Grants Related Experts
All trials for Cornea All trials for Refraction Error All trials of Hormonal Contraception All trials of Combined Oral Contraceptive (COC)

-Summary

Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations

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+Detailed description

Comparing corneal topographic changes and corneal high-order aberrations for women planning to use oral contaceptive pills before and after the usage of the pills

+Arms and interventions

ArmTypeInterventionsDescription
Oral contraceptive pills usersOther: Hormonal Contraception; Drug: Combined Oral Contraceptive (COC)
  • Hormonal Contraception (Other): Effect of usage of hormonal contraceptive pills on corneal topography and corneal high-order aberrations
  • Combined Oral Contraceptive (COC) (Drug): Participants who are prescribed combined oral contraceptive pills as part of routine clinical care will be observed. Corneal topography and tomography will be performed before starting treatment and after the follow-up period to evaluate changes in corneal parameters.

+Outcome measures

Primary outcomes

  • Change in K1 (D) [Baseline and 1 year]
  • Change in K2 (D) [one year]
  • Change in Kmax (D) [one year]
  • change in corneal thickness (um) [one year]

+Eligibility

Sex: Female, ages: 18 Years to 40 Years, accepts healthy volunteers

Inclusion Criteria:

* Female participants aged 18-40 years.
* Prescribed combined oral contraceptive pills as part of routine gynecological care.
* Willing to undergo corneal topography/tomography before starting treatment and after 1 year.
* No previous history of corneal disease or ocular surgery.
* Able to provide informed consent.

Exclusion Criteria:

* Keratoconus or suspected corneal ectasia.
* Corneal opacity, dystrophy, degeneration, or scarring.
* Previous ocular surgery or significant ocular trauma.
* Current contact lens use or recent contact lens use without adequate discontinuation period.
* Active ocular surface disease or severe dry eye.
* Glaucoma, uveitis, retinal disease, or other significant ocular pathology.
* Diabetes mellitus, autoimmune disease, thyroid disease, pregnancy, or lactation.
* Use of other hormonal therapy or systemic medications known to affect corneal parameters.

+Locations (1)

FacilityCityCountryStatus
Ophthalmology Department, Sohag University Hospital, Faculty of Medicine, Sohag UniversitySohag, Sohag GovernorateEgypt