Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study

Patients with paroxysmal or persistent AF undergoing transthoracic echocardiography (TTE) prior to AF ablation will be enrolled and will undergo repeat TTE at 1-year follow-up. The echocardiographic assessment will include standard measurements, right atrial and right ventricular strain analysis, and 3D acquisitions of the tricuspid valve (and mitral valve, if feasible). Tricuspid valve geometry will be analyzed using an AI-powered 3D quantification tool. AF burden will be assessed through serial Holter ECG monitoring at baseline, 3, and 12 months.

The primary endpoint is the difference in 3D tricuspid annular geometry between patients with paroxysmal and persistent AF. Secondary endpoints include interval changes in tricuspid annular geometry over one year, development of ≥ moderate TR, association between AF burden and tricuspid remodeling, identification of echocardiographic predictors of TR progression, and correlation between tricuspid and mitral valve changes.

Study results will be compared with two control groups: (1) subjects without AF and structurally normal hearts, and (2) patients with ≥ moderate atrial functional TR and AF, without significant left-sided valvular disease or prior valve interventions.

Primary outcomes

• Mean 3D Tricuspid Annular Geometry Parameters Measured by 3D Echocardiography in Patients With Paroxysmal vs Persistent Atrial Fibrillation [12 months]

Secondary outcomes

• Change From Baseline in 3D Tricuspid Annular Geometry Parameters Measured by 3D Echocardiography [over 12 months]
• Number of Participants Developing ≥ Moderate Tricuspid Regurgitation Assessed by Echocardiography [12 months]
• Correlation Between Atrial Fibrillation Burden Assessed by Holter ECG and Change in 3D Tricuspid Annular Geometry (and Development of ≥ Moderate Tricuspid Regurgitation) [12 months]
• Association Between Baseline Echocardiographic Parameters and Development of ≥ Moderate Tricuspid Regurgitation [12 months]
• Correlation Between Changes in 3D Tricuspid and Mitral Annular Geometry Measured by 3D Echocardiography [12 months]

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Consecutive patients with atrial fibrillation (paroxysmal or persistent) undergoing transthoracic echocardiography (TTE) prior to AF ablation with acquisition of a 3D TV dataset.

Eligible for enrollment in the control group will be:

1. all consecutive patients with structurally normal hearts and no history of AF or;
2. moderate atrial functional tricuspid regurgitation and AF, in the absence of significant left-sided valvular disease or prior valvular surgery.

Exclusion Criteria:

* Moderate or greater TR assessed using a multiparametric approach;
* Arrhythmias other than AF;
* Prior AF ablations;
* Rapid ventricular response (average HR >110 bpm) during baseline TTE;
* Inadequate image quality

• Gianluca Pontone, MD, Principal investigator, Centro Cardiologico Monzino, IRCCS