The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury

NCT07602465 — Active not recruiting, 5000 participants, Zhongda Hospital

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Registry	NCT07602465
Status	Active not recruiting
Study type	Observational
Enrollment	5000 (Estimated)
Sponsor	Zhongda Hospital (Other); collaborators: Nanjing First Hospital, Nanjing Medical University, The First Affiliated Hospital of Anhui Medical University
Conditions	Acute Kidney Injury (AKI)
Dates	start 2026-06-01, primary completion 2026-12-01 (estimated), completion 2026-12-01 (estimated), first posted 2026-05-22, last updated 2026-09-10
Locations	1 site in China

-Summary

The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.

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+Arms and interventions

Arm	Type	Interventions	Description
HH			High induction blood pressure variability + High surgery blood pressure variability
HL			High induction blood pressure variability + Low surgery blood pressure variability
LH			Low induction blood pressure variability + High surgery blood pressure variability
LL			Low induction blood pressure variability + Low surgery blood pressure variability

+Outcome measures

Primary outcomes

AKI [Within 7 days after surgery.]: AKI diagnosed according to KDIGO criteria within 7 days after surgery was the primary outcome event.

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Undergoing non-cardiac surgery；
* Adult；

Exclusion Criteria:

* Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);
* Surgery duration less than 60 minutes;
* Weight < 30 kg or BMI > 35 kg/m2;
* Patients who underwent reoperation within 7 days after surgery;
* Surgeries not performed under general anesthesia;
* ASA > IV;
* No serum creatinine measurement available within 6 months before surgery (baseline value) or within 7 days after surgery;
* Preexisting renal dysfunction or a diagnosis of chronic kidney disease before surgery (creatinine > 443 μmol/L);
* No invasive blood pressure monitoring during the anesthesia induction period, or missing more than 25% of intraoperative invasive blood pressure data collection.

+Locations (1)

Facility	City	Country	Status
Zhongda Hospital Southeast University	Nanjing, Jiangsu Provincce	China