EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY

NCT07592832 — Not applicable, Not yet recruiting, 60 participants, Harran University

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THE EFFECT OF TWO DİFFERENT ANESTHESİA APPROACHES ON PERİOPERATİVE INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY

Registry	NCT07592832
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, treatment
Enrollment	60 (Estimated)
Sponsor	Harran University (Other)
Conditions	General Anesthesia, Cervical Plexus Block, Thyroid Surgery
Interventions	General Anesthesia, cervical plexus block (Procedure)
Dates	start 2026-07-30 (estimated), primary completion 2027-02-20 (estimated), completion 2027-02-20 (estimated), first posted 2026-05-18, last updated 2026-05-18

-Summary

The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.

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+Arms and interventions

Arm	Type	Interventions	Description
GENERAL ANESTHESIA	Active comparator	Procedure: cervical plexus block	THIS GROUP WILL INCLUDE PATIENTS WHO ARE UNDER GENERAL ANESTHESIA.
cervical plexus block	Active comparator	Procedure: General Anesthesia	IN THIS GROUP, CERVICAL PLEXUS BLOCK WILL BE PERFORMED IN ADDITION TO GENERAL ANESTHESIA.

General Anesthesia (Procedure): In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block. The inflammatory response is a natural response of the body's immune system to surgical trauma, and it can vary depending on the anesthetic agent used. In regulating this response, molecules such as IL-1β, TNF-α, IL-6, IL-10, and IL-40 are important indicators that determine the severity and duration of inflammation. These parameters will be examined and compared in both groups.
cervical plexus block (Procedure): In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block.

+Outcome measures

Primary outcomes

Perioperative Inflammatory Response [Before the procedure, and at 2 and 6 hours after the procedure.]: IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.
Inflammatory Response [Before the procedure, and at 2 and 6 hours after the procedure.]: IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.

+Eligibility

Sex: All, ages: 18 Years to 70 Years

Inclusion Criteria:

* This includes patients aged 18-70 years
* classified as ASA I-III
* who have undergone elective thyroidectomy.

Exclusion Criteria:

* Patients who did not wish to participate in the study voluntarily
* patients for whom superficial cervical block was contraindicated
* pregnant and breastfeeding women
* patients in ASA IV-V groups were excluded from the study.