Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke) (Stroke-CORE)
| Registry | NCT07553650, acronym Stroke-CORE |
|---|---|
| Status | Not yet recruiting |
| Study type | Observational |
| Enrollment | 12750 (Estimated) |
| Sponsor | Charite University, Berlin, Germany (Other); collaborators: Universitätsklinikum Hamburg-Eppendorf, University Hospital Schleswig-Holstein, Wuerzburg University Hospital |
| Conditions | Intracerebral Haemorrhage, Paediatric Stroke, Stroke Acute, Stroke, Ischemic Stroke |
| Dates | start 2026-07-27 (estimated), primary completion 2030-06-30 (estimated), completion 2030-06-30 (estimated), first posted 2026-04-28, last updated 2026-07-09 |
| Locations | 12 sites in Germany |
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All trials for Intracerebral Haemorrhage All trials for Paediatric Stroke
The Stroke-CORE cohort aims to provide a comprehensive and up-to-date understanding of stroke care in Germany. To achieve this, patients are followed along the entire continuum of care-from initial management before hospital admission, through acute treatment, rehabilitation, and follow-up care, to the prevention of recurrent strokes. Strokes occurring in childhood are also included in this cohort study.
In addition, the study seeks to establish effective structures for the early identification and inclusion of patients in clinical research (screening). In this context, structured screening processes are being implemented across all levels of care at participating sites within the Network University Medicine (NUM), a collaboration of German university hospitals. At the same time, the cohort serves as a platform within this network to systematically address open research questions in various areas of stroke care and to support the targeted planning and conduct of future clinical studies.
The study includes patients with ischemic stroke (caused by a blocked blood vessel) or intracerebral hemorrhage (bleeding within the brain). Participation takes place in different thematic modules, each focusing on specific aspects of the disease course and its management. These modules address, among other topics, acute hospital treatment, measures to prevent recurrent strokes (secondary prevention), possible complications, pre-hospital care, rehabilitation, follow-up care, and long-term outcomes such as physical recovery, independence in daily life, and cognitive functions including memory and concentration.
As part of the study, a range of data is collected. This includes sociodemographic information (such as age and living situation) as well as medical data, for example on prior conditions, diagnoses, treatments, and comorbidities. In addition, patients' health status is assessed at multiple time points in order to better understand the course of the disease. Depending on the level of participation, data collection may be complemented by the collection of biological samples, such as blood. These are obtained either during routine clinical procedures or through simple, minimally burdensome (non-invasive) methods.
The study is structured into several levels that differ in the scope and depth of data collection. The basic level includes essential information, while higher levels involve more detailed assessments. In addition, some levels include the collection of biological samples, and there are optional supplementary modules in which patients may participate voluntarily. This tiered approach allows participation to be flexibly adapted to the individual situation while contributing to a nuanced and comprehensive understanding of stroke care.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Ischemic Stroke | This module aims to collect comprehensive, longitudinal data on patients with acute IS to characterise clinical and imaging-derived predictors of outcome. The module is embedded within the broader cohort framework (Level 1) and focuses specifically on causes of IS, treatment during the acute phase, as well as complications, and secondary prevention. Data collection and follow up measures is aligned with the routine collection of quality-assurance data from the German Stroke Registers Study Group ('Arbeitsgemeinschaft Deutschsprachiger Schlaganfall Register' \[ADSR\], https://www.schlaganfallregister.org) and the ICHOM Standard Set for Stroke (https://www.ichom.org/patient-centered-outcome-measure/stroke/). | ||
| Intracerebral Hemorrhage | This module aims to collect data on adult patients presenting with spontaneous intracerebral haemorrhage (ICH). Participants will be characterised regarding demographics, clinical factors, treatment, and imaging features, including haematoma size, location, expansion dynamics, and the presence of spot sign. The study will aim to identify baseline clinical and imaging predictors of in-hospital and 3-month mortality and functional independence, to explore subgroups with distinct prognostic trajectories, and to investigate associations between clinical presentation, imaging parameters, and post-stroke complications. These analyses will inform risk stratification, guide neuroprotective and acute management strategies, and support the development of tailored interventional approaches in ICH. | ||
| Paediatric Stroke |
Sex: All
Inclusion Criteria: * Diagnosis of AIS or ICH; the AIS diagnosis may be diagnosed clinically or radiologically (i.e., focal neurological impairment of sudden onset, lasting more than 24 hours and of presumed vascular origin, or with proof of cerebral ischaemia corresponding to the clinical symptoms in neuroimaging); for ICH diagnosis requires clinical symptoms and radiological diagnosis of ICH * Hospital admission <24h after symptom onset * Age 18+ years for the basic Modules AIS and ICH; age <18 years for the basic Module paediatric stroke patients * Informed consent: Signed IC from patients capable of giving consent and understanding all content of the IC or IC of an appropriate patient representative or deferred consent, if patients are unable to consent themselves * Additional inclusion criteria are defined by the individual Modules Exclusion Criteria: * In-hospital stroke * TIA * SAH * Stroke as a complication of a medical procedure * Enrolment in a randomised placebo-controlled interventional trial * Already enrolled in the SN STROKE base cohort
| Facility | City | Country | Status |
|---|---|---|---|
| Universitätsklinikum Hamburg-Eppendorf (UKE) | Hamburg, Free and Hanseatic City of Hamburg | Germany | |
| Charité University, Berlin, Germany | Berlin, State of Berlin | Germany | |
| Universität Bielefeld, Universitätsklinikum OWL, Evangelisches Klinikum Bethel gGmbH, | Bielefeld | Germany | |
| Universitätsklinikum Carl Gustav Carus Dresden | Dresden | Germany | |
| Universitätsklinikum Erlangen | Erlangen | Germany | |
| Universitätsklinikum Essen | Essen | Germany | |
| Universitätsklinikum Heidelberg | Heidelberg | Germany | |
| Universitätsklinikum Leipzig | Leipzig | Germany | |
| Universitätsklinikum Schleswig-Holstein (UKSH), Campus Lübeck | Lübeck | Germany | |
| Ludwig Maximilians Universität Klinikum | München | Germany | |
| Universitätsklinikum Tübingen | Tübingen | Germany | |
| Universitätsklinikum Würzburg | Würzburg | Germany |