New Treatment of Common Wart

NCT07543926 — Not applicable, Not yet recruiting, 70 participants, Sohag University

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Evaluation Of Intralesional Platelet-Rich Fibrin Versus Intralesional Vitamin D In Treatment Of Common Warts

Registry	NCT07543926
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, treatment
Enrollment	70 (Estimated)
Sponsor	Sohag University (Other)
Conditions	Common Warts (Verruca Vulgaris)
Interventions	PRF group, Vitamin D (Biological, drug)
Dates	start 2026-04-06 (estimated), primary completion 2026-11-30 (estimated), completion 2026-12-30 (estimated), first posted 2026-04-22, last updated 2026-04-22
Locations	1 site in Egypt

-Summary

this study aims to compare the efficacy and safety of platelet rich fibrin injection versus intralesional vitamin D injection in the treatmentof common warts. PRF, as an autologous biological material , may enhance tissue regeneration and immune response.

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+Arms and interventions

Arm	Type	Interventions	Description
group 1 PRF injection	Active comparator	Biological: PRF group
group 2 vitamin D injection	Active comparator	Drug: Vitamin D

PRF group (Biological): intralesional PRF injection in common warts
Vitamin D (Drug): intralesional vitamin D injection in common wart

+Outcome measures

Primary outcomes

treatment of common wart by PRF injection ( Mild response: < 50% reduction in lesion size , Moderate response: ≥ 50% reduction in lesion size , to measure the change in lesion size , is the patient satisfied or not ) [1 session every 2 weeks for 3 months]: treatment of common wart by intralesional injection of PRF
changes in common warts after treatment by PRF (measuring complete clearance and recurrence of the lesions ,asking about patient satisfaction ) [6 months after the last session]

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* \- Age more than or equal to 18 years
* Clinically and dermoscopically confirmed Common warts of both sex
* patient not receiving previous treatment at least one month before recruitment in our study
* Single or multiple lesions suitable for injection.

Exclusion Criteria:

* Chronic Systemic desise (DM , HTN , Autoimmune , immunosuppressive disorders eg , lupus , renal or hepatic failure ) or Hematologic Conditions (anemia : hemoglobin level below 10 g/dl , thrombocytopenia : platelet count below 150,000 /µL ) Infectious Diseases , Local bacterial or fungal infection at the lesions .

Pregnancy, Lactation , patients who has hypersensitivity of vitamin D .

+Locations (1)

Facility	City	Country	Status
Sohag University	Sohag	Egypt