Surgery for Obstructed Gastric Carcinoma

NCT07435025 — Not applicable, Active not recruiting, 63 participants, Zagazig University

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Palliative Resection Versus Palliative Bypass in Obstructed Locally Advanced Gastric Carcinoma

Registry	NCT07435025
Status	Active not recruiting
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, treatment
Enrollment	63 (Estimated)
Sponsor	Zagazig University (Other gov)
Conditions	Gastric Cancer
Interventions	palliative gastric resection, palliative bypass (Procedure)
Dates	start 2026-02-01, primary completion 2027-02-01 (estimated), completion 2027-02-01 (estimated), first posted 2026-02-27, last updated 2026-02-27
Locations	1 site in Egypt

-Summary

The goal of this clinical trial is to find the best treatment for obstructed gastric carcinoma in gastric cancer patients. It will include all patients with obstructed gastric cancer with different ages and sex who consented to share in the trial. The main question is what is the better for management for obstructed gastric cancer; palliative resection or palliative bypass? We hypothesized that resection is better. patients will be divided into two groups. the primary outcome measure will be the relief of obstruction

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+Arms and interventions

Arm	Type	Interventions	Description
Group I: obstructed gastric cancer patients	Active comparator	Procedure: palliative gastric resection	patients presented with emergency gastric obstruction
Group II: obstructed gastric cancer patients	Active comparator	Procedure: palliative bypass	patients presented with emergency gastric obstruction

palliative gastric resection (Procedure): distal, subtotal or total gastrectomy with gastro-jejunostomy or eosphago-jejunostomy will be done
palliative bypass (Procedure): palliative gastro-jejunostomy or eosphago-jejunostomy will be done

+Outcome measures

Primary outcomes

upper gastrointestinal symptoms [from one day to two weeks after surgery]: upper gastrointestinal symptoms will be evaluated after surgery by Rhodes Index questionnaire. It is a validated, self-report instrument used to measure the intensity, frequency, and distress of upper gastrointestinal symptoms. The scale measures three main areas: nausea (frequency, duration, distress), vomiting (amount, frequency, distress), and retching (frequency, distress). It utilizes a 5-point Likert scale (0-4) to quantify the severity of these symptoms. 0 is the least amount of distress and 4 is the most distress.

Secondary outcomes

anastmotic leak [from day one to two weeks after surgery.]: anastmotic site leakage will be assessed by abnormal discharge in the drain calculated in cc.
ICU admission [from day one to two weeks after surgery]: the need of ICU admission will be evaluated by (yes or No)
wound infection [from day one to one month after surgery]: wound infection will be identified by presence of pus in the dressing and positive culture and sensitivity test
mortality [from one day to one month after surgery]: follow up of patient after surgery (died or not)

+Eligibility

Sex: All

Inclusion Criteria:

* emergency obstructed gastric cancer patients

Exclusion Criteria:

* non obstructed gastric cancer patients

+Locations (1)

Facility	City	Country	Status
faculty of medicine, Zagazig University	Zagazig, Sharqia Province	Egypt

+Investigators

Reham Zakaria, M.D, Principal investigator, Zagazig University, Egypt