The Effect of Antegrade Pump Blood Reinfusion Via Crystalloid "Chase" Technique on Postoperative Transfusion Requirements in Adult Cardiac Surgery Patients: A Prospective Observational Study
| Registry | NCT07420582 |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 130 (Actual) |
| Sponsor | Kocaeli City Hospital (Other gov) |
| Conditions | Coronary Artery Disease |
| Interventions | Antegrade Pump Blood Reinfusion, No Anterograde Pump Blood Reinfusion (Procedure, other) |
| Dates | start 2026-02-23, primary completion 2026-08-11, completion 2026-08-18, first posted 2026-02-19, last updated 2026-10-21 |
| Locations | 1 site in Turkey (Türkiye) |
Related Papers Related Patents Related Grants Related Experts
All trials for Coronary Artery Disease All trials of Antegrade Pump Blood Reinfusion All trials of No Anterograde Pump Blood Reinfusion
This prospective observational study aims to evaluate the effect of antegrade pump blood reinfusion using the crystalloid "chase" technique on postoperative transfusion requirements in adult patients undergoing cardiac surgery with cardiopulmonary bypass. At the end of cardiopulmonary bypass, blood remaining within the cardiopulmonary bypass circuit is reinfused antegradely through the arterial line using a crystalloid chase, without collection or storage. Blood remaining within the bypass circuit after surgery represents a valuable source of autologous blood, and its reinfusion may contribute to perioperative blood conservation strategies. Patients receiving antegrade pump blood reinfusion via the chase technique will be compared with those managed without reinfusion, without any intervention by the investigators. The primary outcome is postoperative blood transfusion requirement.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Antegrade Pump Blood Reinfusion (Chase Technique) | Procedure: Antegrade Pump Blood Reinfusion | Adult patients undergoing cardiac surgery with cardiopulmonary bypass in whom antegrade pump blood reinfusion is performed at the end of bypass using the crystalloid chase technique, as part of routine clinical practice. | |
| No Pump Blood Reinfusion | Other: No Anterograde Pump Blood Reinfusion | Adult patients undergoing cardiac surgery with cardiopulmonary bypass in whom antegrade pump blood reinfusion is not performed at the end of bypass, and standard clinical management is applied. |
Sex: All, ages: 18 Years to 80 Years
Inclusion Criteria: * Age 18 to 80 years * Patients undergoing elective, isolated coronary artery bypass grafting surgery using cardiopulmonary bypass (on-pump). Exclusion Criteria: * Emergency or Redo cardiac surgery * Concomitant cardiac procedures (e.g., valve repair/replacement or aortic surgery). * Planned or intraoperative conversion to off-pump coronary artery bypass grafting * Preoperative hematocrit <30% or known inherited/acquired bleeding disorders. * Preoperative left ventricular ejection fraction <30%. * Thrombocytopenia (e.g., platelet count <100×10³/µL) or abnormal coagulation tests. * Use of antiplatelet agents other than aspirin without appropriate discontinuation according to current guideline-recommended preoperative intervals. * Use of anticoagulant therapy without appropriate preoperative discontinuation according to current guideline recommendations. * Use of any intraoperative allogeneic blood product (red blood cells, fresh frozen plasma, or platelets) * Use of non-steroidal anti-inflammatory drugs (NSAIDs) without appropriate discontinuation prior to surgery. * Severe renal dysfunction (eGFR <30 mL/min/1.73 m² or dialysis) and/or severe hepatic dysfunction (Child-Pugh B-C or coagulopathy). * Active infection or systemic inflammatory/autoimmune disease. * Active malignancy requiring ongoing treatment * Refusal or inability to provide written informed consent.
| Facility | City | Country | Status |
|---|---|---|---|
| Kocaeli City Hospital | Kocaeli, Izmit | Turkey (Türkiye) |