Tumor Genomics, Individual Risk Factors, and External Drivers of Health on Health Outcomes for Patients With Meningioma

NCT07418775 — Recruiting, 3000 participants, University of California, San Francisco

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An Investigation of Tumor Genomics, Individual Risk Factors, and External Drivers of Health to Improve Health Outcomes for Patients With Meningioma

Registry	NCT07418775
Status	Recruiting
Study type	Observational
Enrollment	3000 (Estimated)
Sponsor	University of California, San Francisco (Other); collaborators: National Cancer Institute (NCI)
Conditions	Meningioma of Brain, Meningioma, Brain Tumor
Interventions	Questionnaire, Medical Record Review (Behavioral, other)
Dates	start 2026-01-16, primary completion 2031-01-01 (estimated), completion 2032-01-01 (estimated), first posted 2026-02-18, last updated 2026-05-19
Locations	1 site in United States

-Summary

Meningiomas are the most common primary brain tumor, and some groups are diagnosed with higher-grade tumors and have clinically worse outcomes. This study investigates social determinants of health and individual risk factors that may be associated with meningioma.

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+Detailed description

PRIMARY OBJECTIVES:

I. To assess prevalence and distribution of social and structural determinants of health (SSDH) among meningioma patients.

II. To assess disparities in SSDH among meningioma patients of different races.

OUTLINE: This is an observational study.

Participants will complete a survey and have their medical records reviewed.

+Arms and interventions

Arm	Type	Interventions	Description
Participants with Meningioma		Behavioral: Questionnaire; Other: Medical Record Review	Adult patients who have been diagnosed with a meningioma will be asked to complete a one-time survey, which will take roughly 20 minutes to complete. Participants will also have medical records reviewed to capture additional data relating to the participants medical history.

Questionnaire (Behavioral): A questionnaire will be administered in person or online
Medical Record Review (Other): Medical records will be reviewed for study specific data collection

+Outcome measures

Primary outcomes

Identifying potential social and structural determinants of health (SSDH) [Up to 5 years]: The prevalence of SSDH factors such as race and ethnicity, birthplace, relationship status, sexual orientation/gender identity, education level, socio-economic status, access to care, reproductive/menstrual history, health factors and medication use, chemical and radiation exposure, smoking history, and perceived stress for participants with meningioma will be analyzed using multilevel logistic and linear models accounting for geographical clustering.
Distribution of social and structural determinants of health [Up to 5 years]: The distribution of SSDH factors across racial groups will be analyzed using multilevel logistic and linear models accounting for geographical clustering.
Identify disparities in social and structural determinants of health (SSDH) [Up to 5 years]: Disparities of SSDH factors across racial groups will be analyzed using multilevel logistic and linear models accounting for geographical clustering.

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Adults ≥18 years of age
* Able to speak and read English
* Diagnosed with a meningioma

Exclusion Criteria:

* Active psychiatric issues (suicidality, active psychosis, grave disability, etc.)
* Inability to consent secondary to severe neurologic deficit or psychiatric distress
* Inability to complete survey secondary to severe neurologic deficit or psychiatric distress

+Locations (1)

Facility	City	Country	Status
University of California San Francisco	San Francisco, California	United States	Recruiting

+Investigators

David Raleigh, MD, PhD, Principal investigator, University of California, San Francisco, San Francisco, California 94143

+Funding

NIH grants: U54CA302452

My Notes

Public

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