Recurrence Rate and Risk Factors After Endoscopic Resection of Gastric and Intestinal Polyps: A Retrospective and Prospective Cohort Study
| Registry | NCT07314554, acronym RAGIP |
|---|---|
| Status | Not yet recruiting |
| Study type | Observational |
| Enrollment | 2000 (Estimated) |
| Sponsor | LanZhou University (Other) |
| Conditions | Gastric Polyps, Intestinal Polyps, Colon Polyps, Colorectal Polyps, Adenomatous Polyps, Gastric Adenoma and Early Gastric Cancer, Colorectal Adenoma |
| Dates | start 2026-07-26 (estimated), primary completion 2027-02-25 (estimated), completion 2029-02-25 (estimated), first posted 2026-01-02, last updated 2026-06-09 |
| Locations | 1 site in China |
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All trials for Gastric Polyps All trials for Intestinal Polyps
This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.
BACKGROUND: Gastric and intestinal polyps are common digestive diseases with potential for malignant transformation. Although endoscopic resection is the standard treatment, recurrence rates range from 10-50%, and the mechanisms and risk factors remain unclear.
OBJECTIVES:
Primary: To assess short-term (1-year) and long-term (3-year) recurrence rates after endoscopic polyp resection Secondary: To identify independent risk factors and develop a recurrence risk prediction model
DESIGN: Mixed retrospective-prospective cohort study
* Retrospective cohort: Patients who underwent polyp resection from 2021-2022, with follow-up data through 2024
* Prospective cohort: Patients enrolled from 2024-2025, with standardized follow-up through 2028
SETTING: Single tertiary referral center with >10,000 endoscopic polyp resections performed since 2021
PARTICIPANTS: Approximately 1,600-1,800 adult patients (≥18 years) who underwent complete endoscopic resection of gastric or intestinal polyps
FOLLOW-UP:
* Short-term: 1 year post-resection (±2 months)
* Long-term: 3 years post-resection (±3 months)
MAIN OUTCOME: Recurrence rate defined as new polyp detection at original or different sites during endoscopic surveillance
POTENTIAL RISK FACTORS: Patient demographics, polyp characteristics (size, number, location, pathology), resection method, Helicobacter pylori status, lifestyle factors, and medication use
EXPECTED IMPACT: Results will inform personalized surveillance strategies and optimize resource allocation for post-polypectomy follow-up.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Retrospective Cohort | Patients who underwent endoscopic polyp resection from January 2021 to December 2022, with retrospective data collection and follow-up through December 2025 | ||
| Prospective Cohort | Patients undergoing endoscopic polyp resection from October 2024 to December 2025, with prospective standardized data collection and follow-up through December 2028 |
Sex: All, ages: 18 Years to any
Inclusion Criteria: * Age 18 years or older * First-time endoscopic examination (gastroscopy or colonoscopy) at the study center * Pathologically confirmed polyp of any type (adenomatous, hyperplastic, inflammatory, fundic gland polyp, hamartomatous, serrated lesion) * Complete endoscopic resection performed (including EMR, ESD, snare polypectomy, hot biopsy forceps, or argon plasma coagulation) * Negative resection margins or complete resection assessed by pathology * At least one follow-up endoscopic examination completed (for retrospective cohort) or willingness to complete follow-up (for prospective cohort) * Complete baseline clinical data available Exclusion Criteria: * Hereditary polyposis syndromes (familial adenomatous polyposis, Lynch syndrome, Peutz-Jeghers syndrome, juvenile polyposis syndrome) * Inflammatory bowel disease (ulcerative colitis or Crohn's disease) * Previous history of gastric or colorectal cancer * Cancer detected at initial resection (stage T1b or higher) * Non-polyp pathology (e.g., submucosal tumors, normal mucosa) * Incomplete resection with positive margins that were not re-treated * Lost to follow-up with no available surveillance data (for retrospective cohort) * Pregnancy at time of enrollment * Inability or unwillingness to provide informed consent (for prospective cohort)
| Facility | City | Country | Status |
|---|---|---|---|
| The First Hospital of Lanzhou University | Lanzhou, Gansu | China |