Dietary Wild Blueberries and Joint Health

NCT06828159 — Not applicable, Recruiting, 50 participants, University of Nevada, Las Vegas

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Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain

Registry	NCT06828159
Status	Recruiting
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: double, other
Enrollment	50 (Estimated)
Sponsor	University of Nevada, Las Vegas (Other); collaborators: Oklahoma Medical Research Foundation
Conditions	Gut -Microbiota, Inflammation Biomarkers, Pain Assessment, Joint Pain
Interventions	Wild blueberry, Placebo (Dietary supplement)
Dates	start 2025-09-01, primary completion 2027-12-01 (estimated), completion 2028-03-01 (estimated), first posted 2025-02-14, last updated 2025-11-05
Locations	1 site in United States

-Summary

The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.

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+Arms and interventions

Arm	Type	Interventions	Description
Wild blueberries	Experimental	Dietary Supplement: Wild blueberry	25g freeze-dried wild blueberries daily for 12 weeks
Placebo	Placebo comparator	Dietary Supplement: Placebo	Placebo powder free from polyphenols matched for calories

Wild blueberry (Dietary supplement): Freeze-dried wild blueberry powder 25g/day
Placebo (Dietary supplement): Placebo powder matched for calories and no polyphenols

+Outcome measures

Primary outcomes

Serum biomarkers of joint function [12 weeks]: Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires.

Secondary outcomes

Gut microbiome [12 weeks]

+Eligibility

Sex: All, ages: 40 Years to 75 Years

Inclusion Criteria:

* Adults with documented multi-joint/knee arthritis

Exclusion Criteria:

* inability to give informed consent
* pregnancy or lactation
* planned knee replacement surgery
* allergy or contraindication to berries
* recent trauma of the knee responsible of the symptomatic knee
* intra-articular injection in the target knee/hip in the last 3 months
* oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
* use of berry extracts in the last 3 months
* special diets
* cancer treatment
* bone diseases

+Locations (1)

Facility	City	Country	Status
OMRF	Oklahoma City, Oklahoma	United States	Recruiting