Comparison of Oral Isotretinoin vs Ancomparison of Oral Isotretinoin vs Antibiotics on Corneal Thickness With AV

NCT06483971 — Not applicable, Unknown, 36 participants, Superior University

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Comparison of Oral Isotretinoin Versus Ancomparison of Oral Isotretinoin Versus Antibiotics on Corneal Thickness in Patients With Acne Vulgaris

Registry	NCT06483971
Status	Unknown
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, health services research
Enrollment	36 (Actual)
Sponsor	Superior University (Other)
Conditions	Cornea
Interventions	Oral Isotretinoin, Antibiotics (Diagnostic test, combination product)
Dates	start 2023-11-01, primary completion 2024-06-01, completion 2024-10-30 (estimated), first posted 2024-07-03, last updated 2024-07-03
Locations	1 site in Pakistan

-Summary

Comparison of Oral Isotretinoin versus comparison of Oral Isotretinoin versus Antibiotics on Corneal Thickness in Patients with Acne Vulgaris

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+Detailed description

Acne is the most common skin disease requiring attention of health practitioners. It is a self-limiting disease of the pilosebaceous unit, which can lead to devastating and frustrating scars and pigmentary alterations.

+Arms and interventions

Arm	Type	Interventions	Description
Oral Isotretinoin	Other	Diagnostic Test: Oral Isotretinoin
Antibiotics	Experimental	Combination Product: Antibiotics

Oral Isotretinoin (Diagnostic test): 20 mg/kg/day that affects sebaceous glands and is used to treat severe acne Frequency: Once daily
Antibiotics (Combination product): 250 mg on laternate day/3 months Frequency: Once or twice daily

+Outcome measures

Primary outcomes

Optical Coherence Tomography (OCT) [12 Months]: Standardized OCT imaging protocols to ensure consistency and accuracy across all measurements.
Snellen Chart [12 months]: Visual acuity measured at 3-month and 6-month intervals. Units: Snellen fraction (e.g., 20/20, 20/40)

+Eligibility

Sex: All, ages: 20 Years to 43 Years

Inclusion Criteria:

* Patients of either gender shall be enrolled for this study.
* Acne vulgaris patients taking oral isotretinoin and oral antibiotics shall be included.

Exclusion Criteria:

* Patients with any ocular pathology shall be excluded.
* Patients with any systemic pathology other than acne vulgaris shall be excluded.
* Patients with history of contact lens wear, previous refractive surgery or injury shall be excluded.

+Locations (1)

Facility	City	Country	Status
Shalamar Hospital Mughalpura	Lahore, Punjab Province	Pakistan