| Registry | NCT06107439, acronym LIPOKINES |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; na, single group, masking: none, health services research |
| Enrollment | 64 (Actual) |
| Sponsor | Centre Hospitalier Universitaire de la Réunion (Other) |
| Conditions | Lipodystrophy, Dunnigan Syndrome |
| Interventions | Bood and urine sampling (Biological) |
| Dates | start 2023-08-14, primary completion 2025-07-22, completion 2025-07-22, first posted 2023-10-30, last updated 2026-09-16 |
| Locations | 1 site in Reunion |
Related Papers Related Patents Related Grants Related Experts
All trials for Lipodystrophy All trials for Dunnigan Syndrome All trials of Bood and urine sampling
Few data and small numbers affect the inflammatory profile of Dunnigan patients. The levels of certain pro-inflammatory biomarkers would be found higher in these subjects compared to control individuals. However, in these studies, several confounding factors were not taken into account such as smoking, an underlying chronic inflammatory disease such as diabetes and could limit the interpretation of the results. There is no other observation of the anti-inflammatory status of these patients.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| sampling and clinical data collection | Other | Biological: Bood and urine sampling | Participant blood and urine are sampled for inflammatory signal analysis |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: * Adult subject (>18 years old) affected by partial Dunnigan lipodystrophy in the homozygous or heterozygous state (genetic search for the positive mutation carried out before inclusion in the study). * Person affiliated to or beneficiary of a social security scheme. * Free, informed and written consent signed by the participant and the investigator. Exclusion Criteria: * \- Minor * Persons placed under judicial protection, person participating in another research including a period of exclusion still in progress, severely impaired physical and/or psychological health, which, according to the investigator, may affect the participant's compliance with the study * Previous known diabetes * Pregnant woman * Woman who gave birth less than 6 months ago * Breastfeeding in progress * Participation in other research that may have an impact on the evaluation of the main judgment criteria * Hemoglobin b level < 7 mg/dl or < 9-10 mg/dl for patients with cardiovascular or respiratory pathology. * Proven inflammatory pathologies * Anti-inflammatory treatment: taking corticosteroids in the last 3 months. * Active smoking
| Facility | City | Country | Status |
|---|---|---|---|
| CHU La Réunion DRCI | Saint-Pierre | Reunion |