Middle Age muScle Krill Study

NCT06005064 — Not applicable, Completed, 54 participants, University of Glasgow

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The Effect of Krill Oil Supplementation on Muscle Function and Mass in Middle-aged Adults: A Randomised Controlled Trial

Registry	NCT06005064, acronym MASK
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: triple, prevention
Enrollment	54 (Actual)
Sponsor	University of Glasgow (Other)
Conditions	Sarcopenia
Interventions	Krill oil, Vegetable oil (Dietary supplement)
Dates	start 2023-11-01, primary completion 2025-10-01, completion 2025-10-01, first posted 2023-08-22, last updated 2026-04-29
Locations	1 site in United Kingdom

-Summary

This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.

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+Arms and interventions

Arm	Type	Interventions	Description
Intervention	Experimental	Dietary Supplement: Krill oil	Krill oil 4g/day for 24 weeks
Placebo	Placebo comparator	Dietary Supplement: Vegetable oil	Vegetable oil 4g/day for 24 weeks

Krill oil (Dietary supplement): Superba krill oil
Vegetable oil (Dietary supplement): Mixed vegetable oil

+Outcome measures

Primary outcomes

Change in knee extensor maximal isometric torque ( MVC) [Change from baseline to 24 weeks]: Knee extensor maximal isometric torque measured during a maximal voluntary contraction

Secondary outcomes

Change in fat mass [Change from baseline to 24 weeks]: Whole body fat mass measured by measured via bio-electrical impedance
Change in lean mass [Change from baseline to 24 weeks]: Whole body lean mass measured by measured via bio-electrical impedance
Change in omega-3 levels [Change from baseline to 24 weeks]: Red blood cell omega-3 levels
Change in Grip strength [Change from baseline to 24 weeks]: Grip strength measured with a hand held dynamometer
Change in Muscle thickness [Change from baseline to 24 weeks]: Vastus lateralis muscle thickness measured by ultrasound

Other outcomes

Change in systemic inflammation [Change from baseline to 24 weeks]: Plasma levels of C-reactive protein, IL-1, IL-6, IL-8, IL-10, and TNF-α
Change in muscle inflammation [Change from baseline to 24 weeks]: Muscle total protein levels of TNF-α, IL-1β, IL-6, IL-8, MCP-1 and total and phosphorylated levels of NFκB, JNK1/2 and STAT3
Change in muscle anabolic signalling [Change from baseline to 24 weeks]: Muscle total and phosphorylated protein levels of mTOR, IRS-1, Akt, 4EBP-1, p70S6K, RPS6, FOXO-1, GSK3β and total protein levels of MAFBx and MURF-1

+Eligibility

Sex: All, ages: 35 Years to 60 Years, accepts healthy volunteers

Inclusion Criteria:

* Be 35-60 years old
* Have a BMI of less than 35kg/m2

Exclusion Criteria:

* People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
* People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
* People who perform regular (>1 day/week) resistance exercise training.

+Locations (1)

Facility	City	Country	Status
University of Glasgow	Glasgow	United Kingdom