Impact of a History of Tonsillectomy or Adenoidectomy on the Severity of COVID-19 : AMYVID Study

NCT05935566 — Withdrawn, University Hospital, Angers

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Registry	NCT05935566
Status	Withdrawn - no control patients, so study not launched without comparator
Study type	Observational
Sponsor	University Hospital, Angers (Other gov)
Conditions	Tonsillectomy, COVID-19, Adenoidectomy
Interventions	health questionnaire (Other)
Dates	start 2024-03-01 (estimated), primary completion 2024-03-01 (estimated), completion 2024-03-01 (estimated), first posted 2023-07-07, last updated 2024-08-16

-Summary

Little is known about the impact of tonsillectomy and/or adenoidectomy on the severity and presentation of respiratory infections, let alone COVID-19. Current knowledge of the role of NALT suggests that its absence may be associated with an increased risk of severe disease.

Assessing the impact of tonsillectomy and adenoidectomy on the risk of adverse evolution in COVID-19 would help to better identify patients at risk of adverse evolution, so that they can be rapidly offered appropriate treatment. It would also provide a better understanding of the pathophysiology of this infection.

Primary objective: to determine whether there is a link between a history of tonsillectomy or adenoidectomy and the risk of severe COVID-19.

Primary endpoint: proportion of patients with a history of tonsillectomy or adenoidectomy among those hospitalized for severe COVID-19.

The results of this study will be compared with a data-driven study of Covid patients without severe disease.

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+Arms and interventions

health questionnaire (Other): Telephone interview with patient to verify medical history, including tonsillectomy and adenoidectomy.

+Outcome measures

Primary outcomes

Proportion of patients with a history of tonsillectomy or adenoidectomy. [immédiat]

+Eligibility

Sex: All, ages: 18 Years to 80 Years

Inclusion Criteria:

* Adults aged 18 to 80
* Hospitalized in SMIT at CHU d'Angers between 01/03/2020 and 30/11/2021 for severe COVID-19 infection (at least 1 severity criterion)

Exclusion Criteria:

Long-term home oxygen therapy prior to COVID-19 infection

* Vaccination against COVID-19 with at least one dose of vaccine received prior to COVID-19 infection Confidential Page 11 of 15
* Inability to ascertain the presence or absence of a history of tonsillectomy or adenoidectomy
* Person objecting to participation in research