Effect of Ketogenic Diet on Muscle Hypertrophy

NCT05897567 — Not applicable, Unknown, 24 participants, University of Padova

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Effects of Ketogenic Diet on Muscle Hypertrophic Response to Resistance Exercise

Registry	NCT05897567
Status	Unknown
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: single, treatment
Enrollment	24 (Estimated)
Sponsor	University of Padova (Other)
Conditions	Healthy Nutrition
Interventions	resistance training, ketogenic diet, western diet (Other)
Dates	start 2023-06-20, primary completion 2025-03-31 (estimated), completion 2025-12-31 (estimated), first posted 2023-06-09, last updated 2024-05-10
Locations	1 site in Italy

-Summary

The purpose of this study is to investigate the effects of 4 weeks of carbohydrate deprivation (through a ketogenic diet) on hypertrophy signalling after a single bout of exercise in healthy trained male subjects, and the impact on body composition, muscle strength, and blood parameters.

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+Arms and interventions

Arm	Type	Interventions	Description
ketogenic diet	Experimental	Other: resistance training; Other: ketogenic diet	Participants will perform a single exercise bout after 4 weeks of resistance training combined with a ketogenic diet (KD group).
western diet	Active comparator	Other: resistance training; Other: western diet	Participants will perform a single exercise bout after 4 weeks of resistance training combined with a western diet (WD group).

resistance training (Other): All participants perform a four-day resistance training aimed to stimulate a hypertrophic response.
ketogenic diet (Other): Subjects allocated to the ketogenic diet arm (KD group) consume less than 50 g of carbohydrates per day.
western diet (Other): Subjects allocated to the western diet arm (WD group) consume a standard diet based on 55% of their daily calories from carbohydrates.

+Outcome measures

Primary outcomes

mammalian target of rapamycin (mTOR) signalling [Change from baseline to 4 weeks]: Measurement of the change in muscle protein anabolic signalling pathway in response to a single bout of resistance exercise by western blot analysis.

Secondary outcomes

Skeletal muscle mass [Change from baseline to 4 weeks]: Measurement of the change in kilograms of muscle mass via Dexa

+Eligibility

Sex: Male, ages: 18 Years to 50 Years, accepts healthy volunteers

Inclusion Criteria:

* at least 2 years of resistance-training experience
* Body mass index: more than 18 kg/m2 and less than 30 kg/m2

Exclusion Criteria:

* metabolic diseases or noncommunicable diseases (cardiovascular, liver, respiratory, cancer, etc)
* experience with the ketogenic diet (last six months)
* acute inflammatory status
* treatment with steroids in the past 3 months

+Locations (1)

Facility	City	Country	Status
Nutex LAB	Padua	Italy	Recruiting

+Investigators

Antonio Paoli, MD, Principal investigator, University of Padova