Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients

NCT05825638 — Completed, 12 participants, Groupe Hospitalier du Havre

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.

Registry	NCT05825638
Status	Completed
Study type	Observational
Enrollment	12 (Actual)
Sponsor	Groupe Hospitalier du Havre (Other); collaborators: Medrinal Clement, Combret Yann, Machefert Margaux
Conditions	COPD, Exercise, Pulmonary Rehabilitation, Desaturation of Blood
Interventions	Continuous training session, Interval training session (Other)
Dates	start 2023-01-10, primary completion 2025-09-30, completion 2025-10-10, first posted 2023-04-24, last updated 2026-01-21
Locations	1 site in France

-Summary

A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients.

The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
Continuous training session		Other: Continuous training session
Interval Training session		Other: Interval training session

Continuous training session (Other): Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power
Interval training session (Other): Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.

+Outcome measures

Primary outcomes

Difference in oxygen pulsed saturation [One week]: Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)

Secondary outcomes

Difference in oxygen pulsed saturation [One week]: Difference in mean pulsed oxygen saturation and the time spent with a pulsed oxygen saturation below 90% during the two training sessions. The measurement will be performed with a pulse oximeter (Spirodoc, MIR)
Difference in peripheral muscle oxygenation [One week]: Muscle oxygenation (arbitrary unit) will be evaluated using Near-infrared spectroscopy technology. the measurement will be performed with a Near Infrared spectroscopy (Portamon, Artinis Medical Systems)
Difference in respiratory rate [One week]: Difference in respiratory rate will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)
Difference in tidal volume [One week]: Difference in tidal volume will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)
Difference in inspiratory capacity [One week]: Difference in inspiratory capacity will be measured using a portable spirometer (Spirodoc, MIR)
Difference in Dyspnea [One week]: Dyspnea peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea
Difference in muscle discomfort [One week]: Muscle discomfort peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea

+Eligibility

Sex: All

Inclusion Criteria:

* a diagnosis of COPD
* participating in a pulmonary rehabilitation programme
* with an exercise-induced desaturation less than 90%
* no oxygen supplementation

Exclusion Criteria:

* Under 18 years of age
* Pregnant woman
* Person not affiliated to a health insurance regime or not benefiting from a social security regime
* Patient under curatorship, guardianship or safeguard of justice
* Patient speaking a language other than French
* Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise
* Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks
* Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort
* Breastfeeding women

+Locations (1)

Facility	City	Country	Status
Groupe Hospitalier du Havre	Le Havre, Normandy	France

+Investigators

Guillaume Prieur, PT, PhD, Principal investigator, Groupe Hospitalier du Havre