Time Lapse Assisted Embryo Selection Versus Non Invasive PGT-A Assisted Embryo Selection

A randomized prospective study focusing on subfertile women undergoing IVF treatment followed by embryo transfer on the blastocyst stage.

Women assigned to group A proceed to embryo transfer, after time lapse assisted embryo selection, while women of group B after non-invasive PGT-A assisted embryo selection.

IVF outcomes, regarding the success rate of the trasnfer and the time required to achieve conception is studied in both groups.

• embryo selection (Other): The basis of embryo seletion for transfer: morphological or genetic after non-invasive PGT-A

Primary outcomes

• Embryotransfers to conceive [Up to the embryotransfer of the last enrolled patient (Dec 2023)]: The number of the embryotransfers required for women to conceive
• Time interval to conceive [Up to the pregnancy test after the last embryo transfer of an enrolled patient (Jan 2024)]: Time interval required for women to conceive (in months): from OPU day to positive hCG test
• Cumulative Live Birth Rate [Up to 38 weeks after the embryo transfer]: Cumulative Live Birth Rate achieved after one OPU treatment

Secondary outcomes

• Abortion rate [Up to 2nd trimester miscarriages]: The spontaneous miscarriage of women in both groups
• DaC rate [Up to 24 weeks of pregnancy according to Greek Law]: The rate of the dilation and curretage rate in both groups

Sex: Female, ages: 18 Years to 39 Years, accepts healthy volunteers

Inclusion Criteria:

* Women who followed IVF treatment
* 39 years old or younger
* Single embryo transfer
* blastocyst stage cultured embryos

Exclusion Criteria:

* women over the age of 39 years
* not blastocyst transfer (transfers performed at earlier embryo stage)
* double embryotransfer
* women who had invasive PGT-a test
* women whose embryos were not time-lapse monitored

• Evangelos Papanikolaou, MD,PhD, Principal investigator, Assisting Nature