Assessment of Serum Asprosin Level in Male Patients With Acne Vulgaris

NCT05471388 — Not applicable, Unknown, 72 participants, Sohag University

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Registry	NCT05471388
Status	Unknown
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, other
Enrollment	72 (Estimated)
Sponsor	Sohag University (Other)
Conditions	Acne Vulgaris
Interventions	serum asprosin (Diagnostic test)
Dates	start 2022-07-18 (estimated), primary completion 2023-01-18 (estimated), completion 2023-01-18 (estimated), first posted 2022-07-22, last updated 2022-07-22
Locations	1 site in Egypt

-Summary

Subject of interest is to evaluate serum level of asprosin in male patients with acne vulgaris, demonstrate the relation between acne vulgaris severity and level of asprosin in these patients \& the relation between metabolic syndrome in acne vulgaris and level of asprosin.

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+Arms and interventions

Arm	Type	Interventions	Description
case	Active comparator	Diagnostic Test: serum asprosin
control	Active comparator	Diagnostic Test: serum asprosin

serum asprosin (Diagnostic test): assessment of serum asprosin by a commercially available double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit.

+Outcome measures

Primary outcomes

Assess serum asprosin level in male patients with acne vulgaris. [6 months]: Assess serum asprosin level in male patients with acne vulgaris.

+Eligibility

Sex: Male, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Acne vulgaris male patients (>18 years) will be included.

Exclusion Criteria:

* Age <18 years.
* Females.
* Patients with other inflammatory skin disorders.
* Patients with associated systemic diseases.
* Current or previous treatment with isotretinoin in the last 3 month ,anti-inflammatory drugs, systemic antibiotics, androgen or anti androgen therapy, and steroid therapy).
* Patients known on treatment of diabetes, hypertension and dyslipidemia.
* Athletes.
* Patient refusal.

+Locations (1)

Facility	City	Country	Status
Sohag University Hospital	Sohag	Egypt

+Publications

Rocha MA, Bagatin E. Adult-onset acne: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol. 2018 Feb 1;11:59-69. doi: 10.2147/CCID.S137794. eCollection 2018. PMID 29440921
Kovacs D, Fazekas F, Olah A, Torocsik D. Adipokines in the Skin and in Dermatological Diseases. Int J Mol Sci. 2020 Nov 28;21(23):9048. doi: 10.3390/ijms21239048. PMID 33260746
Nagpal M, De D, Handa S, Pal A, Sachdeva N. Insulin Resistance and Metabolic Syndrome in Young Men With Acne. JAMA Dermatol. 2016 Apr;152(4):399-404. doi: 10.1001/jamadermatol.2015.4499. PMID 26720707
Hong T, Li JY, Wang YD, Qi XY, Liao ZZ, Bhadel P, Ran L, Yang J, Yan B, Liu JH, Xiao XH. High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome. Int J Endocrinol. 2021 Mar 2;2021:6622129. doi: 10.1155/2021/6622129. eCollection 2021. PMID 33747078