Sensory Memory in Speech Motor Learning

NCT04818268 — Not applicable, Terminated, 120 participants, Yale University

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Role of Sensory Working Memory in Speech Motor Learning Aim 2

Registry	NCT04818268
Status	Terminated - End of funding
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, basic science
Enrollment	120 (Actual)
Sponsor	Yale University (Other); collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions	Speech, Consolidation
Interventions	Adaptation, cTBS (Behavioral, other)
Dates	start 2019-08-01, primary completion 2025-07-31, completion 2025-07-31, first posted 2021-03-26, last updated 2026-05-28
Locations	1 site in Canada

-Summary

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

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+Detailed description

This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

+Arms and interventions

Arm	Type	Interventions	Description
Adaptation to Altered Auditory Feedback	Experimental	Behavioral: Adaptation	Adaptation to Altered Auditory Feedback
Auditory Sensory Memory	Experimental	Behavioral: Adaptation	Auditory Sensory Memory
Somatosensory Sensory Memory	Experimental	Behavioral: Adaptation	Somatosensory Sensory Memory
Adaptation to Altered Auditory Feedback + cTBS to 46v	Experimental	Behavioral: Adaptation; Other: cTBS	Adaptation to Altered Auditory Feedback + cTBS to 46v
Sensory Memory + cTBS to 46v	Experimental	Behavioral: Adaptation; Other: cTBS	Sensory Memory + cTBS to 46v

Adaptation (Behavioral): Sensorimotor adaptation in speech
cTBS (Other): continuous theta-burst stimulation

+Outcome measures

Primary outcomes

Speech Motor Learning [Performance as measured at the end of learning (single day experiment)]: Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.
Sensory Memory [Single day experiment]: Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.

+Eligibility

Sex: All, ages: 21 Years to 40 Years, accepts healthy volunteers

Inclusion Criteria:

* right handed adults
* no known physical or neurological abnormalities

Exclusion Criteria:

* patients with:
* cardiac pacemaker
* surgical clips or values on the heart
* implants
* metal or metallic fragments in any part of the body
* pregnancy
* claustrophobia
* a personal or family history of epilepsy
* currently taking antipsychotic drugs
* currently taking antidepressant drugs
* currently taking antianxiety drugs
* history of concussion.

+Locations (1)

Facility	City	Country	Status
McGill University	Montreal, Quebec	Canada

+Study documents

Informed Consent Form (PDF, 2019-06-15)

+Investigators

David Ostry, Principal investigator, Haskins Laboratories

+Funding

NIH grants: R01DC017439