Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses in Obese/Overweight Males During Submaximal Exercise
| Registry | NCT04465110 |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, crossover, masking: double, prevention |
| Enrollment | 10 (Actual) |
| Sponsor | California Baptist University (Other) |
| Conditions | Obesity Adult Onset |
| Interventions | Grape Seed Extract (Dietary supplement) |
| Dates | start 2019-09-01, primary completion 2020-04-22, completion 2020-04-22, first posted 2020-07-09, last updated 2020-07-13 |
| Locations | 1 site in United States |
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It was demonstrated that acute dietary supplementation with GSE reduced arterial blood pressure via reduction in Q in obese individuals. However, no studies have investigated the chronic effects of dietary GSE supplementation on hemodynamic responses during exercise. Given the fact that obesity is associated with an impaired function of eNOS, the effect of chronic dietary GSE supplementation on abnormal blood pressure response to exercise and aortic stiffness (AoS) needs be elucidated. Thus, it is hypothesized that GSE decreases systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), Q, and aortic stiffness at rest and during exercise. This study would determine that this supplementation may be used as a non-pharmacological intervention to prevent incident hypertension and cardiovascular events during exercise via enhanced endothelial function.
We investigated whether elevated blood pressure and aortic stiffness (AoS) characterized in obese and overweight males (N=10) are reduced following chronic GSE supplementation during exercise. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total vascular conductance (TVC), and AoS to two submaximal cycling exercises (40% and 60% VO2peak) were compared 7 days after ingestion of GSE or placebo (PL) within an one week washout period. Compared with PL, GSE supplementation significantly decreased MAP at rest, 40%, and 60% workloads. AoS was significantly reduced at rest. Q tended to be decreased, but there was no significant difference. GSE had no effect on HR, TVC, and SV. Our study indicates that chronic supplementation with GSE reduces arterial pressure at rest and during exercise primarily via the combined reduction of AoS and Q. Thus, GSE can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| GSE group | Experimental | Dietary Supplement: Grape Seed Extract | Subjects took a single dose of 600 mg GSE in capsule form through ingestion 7 days |
| Placebo group | Placebo comparator | Dietary Supplement: Grape Seed Extract | Subjects took a single dose of 600 mg starch in capsule form through ingestion 7 days |
Sex: Male, ages: 18 Years to 29 Years, accepts healthy volunteers
Inclusion Criteria: * Overweight: 25-29.9 kg/m2 * Obese: > 30 kg/m2 * Waist circumference: > 90 cm Exclusion Criteria: * Antihypertensive medication * Major systemic disease (cancer) * Musculoskeletal diseases * Cardiovascular diseases or symptoms including chest pain * Myocardial infarction * Arrhythmias * Heart failure
| Facility | City | Country | Status |
|---|---|---|---|
| California Baptist University | Riverside, California | United States |