Saliva Profiles in Children With Congenital Heart Disease

NCT03457974 — Not applicable, Completed, 84 participants, Istanbul University

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Registry	NCT03457974
Status	Completed
Phase	Not applicable
Study type	Interventional; non randomized, parallel, masking: single, diagnostic
Enrollment	84 (Actual)
Sponsor	Istanbul University (Other); collaborators: Figen Seymen, Merve Bayram, Ezel Uslu, Sule Batu, Yegane Güven
Conditions	Cardiac Disease, Dental Caries
Interventions	saliva (Other)
Dates	start 2011-01-01, primary completion 2012-01-01, completion 2012-01-01, first posted 2018-03-08, last updated 2018-03-08

-Summary

The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.

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+Detailed description

Using heart failure medications may cause low salivary pH and buffering capacity.As improved oral health is a priority for cardiac patients, it is necessary that they attend dental clinics for regular follow up.

This cross sectional study was carried out with 42 CHD and 42 healthy children who applied to Istanbul University, Faculty of Dentistry, Department of Pedodontics. Gender, age, general health and medications, and caries scores (dfs/DMFS) were recorded. Unstimulated saliva was collected from the participants and were assessed for the salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

+Arms and interventions

Arm	Type	Interventions	Description
congenital heart disease	Experimental	Other: saliva	42 patients
helathy children	Other	Other: saliva	42 children

saliva (Other): salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.

+Outcome measures

Primary outcomes

salivary secretion rate [2 hour]: salivary secretion rate
salivary buffering capacity [2 hour]: salivary buffering capacity
pH [2 hour]: pH

Secondary outcomes

protein levels of saliva [2 hour]: protein levels
superoxide dismutase (SOD) [2 hour]: superoxide dismutase (SOD)
ferric reducing antioxidant power (FRAP) [2 hour]: ferric reducing antioxidant power (FRAP)
the thiobarbituric acid reactive substances (TBARS) [2 hour]: the thiobarbituric acid reactive substances (TBARS)

Other outcomes

protein carbonyl [2 hour]: protein carbonyl
protein thiols [2 hour]: protein thiols
total sialic acid [2 hour]: total sialic acid

+Eligibility

Sex: All, ages: 3 Years to 12 Years, accepts healthy volunteers

Inclusion Criteria:

* 3-12 years
* Caridac problems

Exclusion Criteria:

* other ages
* syndromes
* other systemic diseases

My Notes

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