Effects of Concord Grape Juice Alone on Glycemia, Appetite and Cognitive Function in Healthy Adults

NCT03409484 — Not applicable, Completed, 40 participants, Purdue University

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Registry	NCT03409484
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: single, basic science
Enrollment	40 (Actual)
Sponsor	Purdue University (Other); collaborators: Welch's Food Corporation
Conditions	Glycemic Response, Appetitive Behavior
Interventions	Concord Grape Juice, Low flavoniod low essence beverage, Low flavonoid beverage (Other)
Dates	start 2018-10-10, primary completion 2019-03-28, completion 2019-09-20, first posted 2018-01-24, last updated 2020-11-05
Locations	1 site in United States

-Summary

Assess the impact of 100% grape juice on postprandial glycemic response and subsequent appetite, food intake and cognitive function.

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+Detailed description

Investigators earlier clinical work and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on appetite and glycemia. Investigators aim to better understand the use of 100% grape juice modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.

+Arms and interventions

Arm	Type	Interventions	Description
Concord Grape Juice	Active comparator	Other: Concord Grape Juice	100% Concord Grape Juice
Low flavonoid low essence beverage	Sham comparator	Other: Low flavoniod low essence beverage	Low flavonoid low essence beverage
Low flavonoid beverage	Sham comparator	Other: Low flavonoid beverage	Low flavonoid beverage

Concord Grape Juice (Other): Concord Grape Juice
Low flavoniod low essence beverage (Other): Low flavoniod low essence beverage
Low flavonoid beverage (Other): Low flavonoid beverage

+Outcome measures

Primary outcomes

Change in blood glucose over 24 hours [24 hours]: samples taken every 5 minutes for 24 hours by a continuous glucose monitor

Secondary outcomes

Appetite [24 hours]: Questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly on same day as grape juice intervention

+Eligibility

Sex: All, ages: 25 Years to 60 Years, accepts healthy volunteers

Inclusion Criteria:

* BMI between 25.0-34.9 kg/m2
* Willingness to eat all test foods
* Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day.
* Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA)

Exclusion Criteria:

* Taking medications known to affect glycemia, lipid metabolism or appetite
* Body weight fluctuation of >5kg in the past 3 months
* Taking vitamin or other supplements
* Smokers
* Acute or Chronic disease

+Locations (1)

Facility	City	Country	Status
Purdue University	West Lafayette, Indiana	United States

+Publications

Results publication: Coelho OGL, Alfenas RCG, Debelo H, Wightman JD, Ferruzzi MG, Mattes RD. Effects of Concord grape juice flavor intensity and phenolic compound content on glycemia, appetite and cognitive function in adults with excess body weight: a randomized double-blind crossover trial. Food Funct. 2021 Nov 15;12(22):11469-11481. doi: 10.1039/d1fo02049h. PMID 34698750

+Investigators

Richard D Mattes, PhD, Principal investigator, Purdue University

My Notes

Public

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