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Reported Time Between Onset and Diagnosis of Alzheimer's Disease: Correlation With Objective Parameters

NCT03408041 — Completed, 129 participants, Murielle Surquin

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RegistryNCT03408041
StatusCompleted
Study typeObservational
Enrollment129 (Actual)
SponsorMurielle Surquin (Other)
ConditionsAlzheimer Disease
InterventionsMedical file data extraction (Other)
Datesstart 2016-05-01, primary completion 2017-10-01, completion 2017-10-01, first posted 2018-01-23, last updated 2018-01-23
Locations1 site in Belgium

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-Summary

The early diagnosis of Alzheimer's disease is essential to enable patients to have access to the available treatments. However, there is a delay between the diagnosis and the onset of symptoms, which can range from 1 year to more than 5 years. In clinical practice, the hippocampal volume, measured by the Scheltens index, is currently used as a marker of the progression of the disease.

The purpose of this study is to determine whether the patient's sex, age and ethnicity can influence the delay in the expression of cognitive troubles reported by the family at the first medical consultation, as well as to determine if there is a correlation between the delay reported by the family and the Scheltens index.

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+Arms and interventions

ArmTypeInterventionsDescription
Alzheimer DiseaseOther: Medical file data extractionAlzheimer Disease patients admitted in the 'Memory Clinic' of the CHU Brugmann Hospital between 01-01-2010 and 31-01-2013. Diagnose according to the Dubois criteria
  • Medical file data extraction (Other): Medical file data extraction

+Outcome measures

Primary outcomes

  • Age [Between 01-01-2010 and 31-01-2013]: Age
  • Sex [Between 01-01-2010 and 31-01-2013]: Sex
  • Ethnic origin [Between 01-01-2010 and 31-01-2013]: Ethnic origin
  • Symptoms-diagnose time interval [Between 01-01-2010 and 31-01-2013]: Interval of time between the apparition of the first symptoms, as reported by the family, and the diagnose.
  • Scheltens scale [Between 01-01-2010 and 31-01-2013]: Evaluation of the hippocampal atrophy by means of magnetic resonance imaging. Scale from 0 (normal) to 4.

+Eligibility

Sex: All

Inclusion Criteria:

Alzheimer Disease patients admitted in the 'Memory Clinic' of the CHU Brugmann Hospital between 01-01-2010 and 31-01-2013. Diagnose according to the Dubois criteria

Exclusion Criteria:

None

+Locations (1)

FacilityCityCountryStatus
CHU BrugmannBrusselsBelgium

+Investigators

My Notes