Imaging Response to Immunotherapy and Radiation Therapy in Patients With Liver Metastases

NCT03401814 — Completed, 1 participants, Mayo Clinic

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Registry	NCT03401814
Status	Completed
Study type	Observational
Enrollment	1 (Actual)
Sponsor	Mayo Clinic (Other)
Conditions	Liver Metastases
Interventions	Magnetic Resonance Elastography (Other)
Dates	start 2018-08-02, primary completion 2019-12-12, completion 2019-12-12, first posted 2018-01-17, last updated 2021-07-09
Locations	1 site in United States

-Summary

Patients will be imaged with MRE at the time of the RT planning MRI, prior to the induction of RT and immunotherapy. Research imaging will be in addition to standard imaging studies performed at time points consistent with the standard of care (at the time of the RT planning MRI and the first clinical follow-up). An additional MRE exam will be performed at the end of treatment outside the standard of care imaging.

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+Arms and interventions

Magnetic Resonance Elastography (Other), also known as MRE: rapidly developing technology for quantitatively assessing the mechanical properties of tissue, using externally applied mechanical waves

+Outcome measures

Primary outcomes

Quantify tissue mechanical properties of the liver and liver tumor using MRE in patients receiving radiation therapy + immunotherapy at baseline, mid-treatment and time of followup imaging determined by standard of care to assess response to therapy [1 year]

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Age ≥ 18 years
* Diagnosis of solid cancers with the presence of one or more liver metastases
* Minimum metastasis diameter ≥ 2 cm
* Planning to receive radiation therapy with immunotherapy
* Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester

Exclusion Criteria:

* Contraindications for MRI including claustrophobia, pace maker, metal implants, aneurism clips
* Patients who are not able to consent

+Locations (1)

Facility	City	Country	Status
Mayo Clinic	Rochester, Minnesota	United States

+Investigators

Sean Park, MD, Principal investigator, Mayo Clinic

My Notes

Public

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