Air Purifier to Improve Endothelial Function and Carotid Intima Thickness

NCT03301402 — Not applicable, Completed, 61 participants, Chinese University of Hong Kong

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

A Randomized Controlled Trial of Air Purifier to Improve Endothelial Function and Carotid Intima Thickness in Older Diabetic People With Cognitive Impairment

Registry	NCT03301402
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: quadruple, other
Enrollment	61 (Actual)
Sponsor	Chinese University of Hong Kong (Other)
Conditions	Endothelial Function, Cognitive Impairment
Interventions	Air purifier (Device)
Dates	start 2017-09-22, primary completion 2021-01-05, completion 2021-01-05, first posted 2017-10-04, last updated 2021-06-01
Locations	1 site in Hong Kong

-Summary

Background: There is epidemiological evidence or link ambient air pollution exposure to the incidence of dementia.

Aims or hypotheses: It is hypothesized that reduction in indoor pollutants from air purification improves endothelial function and carotid intima thickness in older diabetic people with cognitive impairment.

Subjects and method: People with clinically diagnosis mild cognitive impairment or early dementia will be recruited. After obtaining written consent, the subjects will be assessed cognitive function and arterial health. After baseline measurements, the subjects are randomly assigned to have either filter or no filter installed in the air purifier. The air purifier will be placed in living room of the household of the subject for one year. At one year, the measurements will be repeated.

Statistical analysis: Intention to treat analysis will be adopted.

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
Filter	Active comparator	Device: Air purifier
No filter	No intervention

Air purifier (Device): Air purifier with filter at automatic mode on all time

+Outcome measures

Primary outcomes

FMD% [12 months]: Endothelial function will be assessed by Flow mediated dilatation of brachial artery

+Eligibility

Sex: All, ages: 70 Years to any

Inclusion Criteria:

* Diabetic people
* Mild cognitive impairment or early dementia

Exclusion Criteria:

* Current smoker
* The presence of a smoker in the household
* The absence of a reliable family caregiver
* The lack of mental capacity to give informed consent

+Locations (1)

Facility	City	Country	Status
The Chinese University of Hong Kong	Hong Kong	Hong Kong

+Investigators

Timothy Kwok, Principal investigator, Chinese University of Hong Kong

My Notes

Public

To Read Reading Read