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Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis

NCT03282253 — Unknown, 216 participants, Nanjing University School of Medicine
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Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity and Clinical Outcomes of Severe Acute Pancreatitis

RegistryNCT03282253
StatusUnknown
Study typeObservational
Enrollment216 (Estimated)
SponsorNanjing University School of Medicine (Other)
ConditionsAcute Pancreatitis, Organ Failure, Multiple
Datesstart 2018-01-01 (estimated), primary completion 2018-12-30 (estimated), completion 2019-06-30 (estimated), first posted 2017-09-13, last updated 2017-11-27

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-Summary

In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.

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+Outcome measures

Primary outcomes

  • the incidence rate of infected pancreatic necrosis [2-4 week after disease onset]

Secondary outcomes

  • the incidence rate of organ failure [1-2 week after disease onset]: the incidence rate of organ failure (transient or persistent)
  • the incidence rate of local complications [1-2 week after disease onset]: acute peripancreatic fluid collections, pancreatic pseudocycts, acute necrotic collections and walled-off necrosis

+Eligibility

Sex: All, ages: 18 Years to 75 Years, accepts healthy volunteers

Inclusion Criteria:

1. Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission;
2. APACHEII score is more than 8 and Ranson score is greater than 3;
3. Age 18-75;
4. Obtaining informed consent.

Exclusion Criteria:

1. Pregnancy pancreatitis;
2. Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease.

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