| Registry | NCT03281252 |
|---|---|
| Status | Unknown |
| Study type | Observational |
| Enrollment | 100 (Estimated) |
| Sponsor | Nanfang Hospital, Southern Medical University (Other) |
| Conditions | Liver Failure, Acute on Chronic, Hemostatic Disorder |
| Dates | start 2017-04-16, primary completion 2017-09-16 (estimated), completion 2017-09-16 (estimated), first posted 2017-09-13, last updated 2017-09-13 |
| Locations | 1 site in China |
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All trials for Liver Failure, Acute on Chronic All trials for Hemostatic Disorder
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. However, the minor and major bleeding events has not been described yet. We observe the patients' major and minor bleeding events and use 4 criteria, which include BARC, ISTH, TIMI, Gusto ,to evaluate the incident rate of bleeding events in ACLF patients and pre-ACLF patients.
Sex: All, ages: 18 Years to 80 Years
Inclusion Criteria: * patient with previously or undiagnosed chronic liver disease/cirrhosis; * serum bilirubin higher than 3 mg/dl (51 mmol/L) or ALT>10ULN（male 300 U/L; female 200 U/L) Exclusion Criteria: * those who had or been diagnosed hepatocellular carcinoma or other types of malignancies; * pregnancy; * obstructive biliary diseases or other disease lead to bilirubin evaluation; * using steroid or immunosuppressant in 4 weeks; * prior surgeries including splenectomy，subtotal splenectomy and disconnection，liver transplantation. * combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS<8)
| Facility | City | Country | Status |
|---|---|---|---|
| Nanfang Hospital | Guangzhou, Guangdong | China | Recruiting |