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Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale

NCT03243994 — Not applicable, Completed, 14 participants, Jens Rikardt Andersen
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Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease Complicated by Cor Pulmonale: A Pilot Study

RegistryNCT03243994
StatusCompleted
PhaseNot applicable
Study typeInterventional; non randomized, parallel, masking: none, diagnostic
Enrollment14 (Actual)
SponsorJens Rikardt Andersen (Other)
ConditionsChronic Obstructive Pulmonary Disease, Cor Pulmonale
InterventionsAbsorption test with D-xylose and zink (Diagnostic test)
Datesstart 2016-02-01, primary completion 2016-10-01, completion 2016-10-01, first posted 2017-08-09, last updated 2017-08-09

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-Summary

Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale potentially due to venous obstruction in the portal vein system.

The presence of cor pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.

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+Detailed description

Background: Cor pulmonale is a common complication to Chronic Obstructive Pulmonary Disease (COPD), and may result in increased pressure in the inferior caval vein and stasis of the liver. The chronic pulmonary hypertension may lead to stasis in the veins from the small intestine and thereby compromise absorption of nutrients.

Aim: To investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to COPD patients without cor pulmonale.

Methods: Absorption of D-xylose (25 g) and zinc (132 mg), administered as a single dose, was tested in 14 COPD patients, seven with and seven without cor pulmonale. The presence of cor pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.

+Arms and interventions

ArmTypeInterventionsDescription
COPDExperimentalDiagnostic Test: Absorption test with D-xylose and zinkPatients with COPD without Cor Pulmonale
COPD + Cor PulmonaleExperimentalDiagnostic Test: Absorption test with D-xylose and zinkPatients with Cor Pulmonale in addition
  • Absorption test with D-xylose and zink (Diagnostic test): Absorption of D-xylose (25 g) and zinc (132 mg), administered as a single dose. The concentration of D-xylose and zinc was measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. Furthermore, urine was collected for five hours to determine the amount of excreted D-xylose.

+Outcome measures

Primary outcomes

  • Absorption fraction of D-xylose [3 hours]: plasma concentration, mmol/l

Secondary outcomes

  • Absorption of zinc [3 hours]: plasma concentration, micromol/l
  • Absorption fraction of D-xylose [5 hours]: urine excretion, mmol

+Eligibility

Sex: All, ages: 60 Years to any

Inclusion Criteria:

* A diagnosis of COPD
* Clinically stable = Unchanged medication for COPD for at least 6 months

Exclusion Criteria:

* Unable to understand Danish
* Other clinically important heart-disease than chronic right heart changes presumably due to lung disease
* Clinically significant gastro-intestinal or kidney disease
* Diabetes
* Treatment with corticosteroids for at least 6 months.

+Investigators

My Notes