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Predicting the Severity of Post-cesarean Wound Infections Using Serum Procalcitonin Levels

NCT03223233 — Completed, 90 participants, Kanuni Sultan Suleyman Training and Research Hospital
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RegistryNCT03223233
StatusCompleted
Study typeObservational
Enrollment90 (Actual)
SponsorKanuni Sultan Suleyman Training and Research Hospital (Other)
ConditionsWound Infection, Cesarean Wound Disruption
Interventionsprocalcitonin level (Other)
Datesstart 2017-05-02, primary completion 2017-09-29, completion 2017-10-08, first posted 2017-07-21, last updated 2017-10-24
Locations1 site in Turkey (Türkiye)

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-Summary

The serum procalcitonin levels are important during infections and sepsis. The investigators aimed to assess its predictive value in terms of post-cesarean wound infection.

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+Detailed description

The serum procalcitonin levels are important during infections and sepsis. Recent studies showed that serum procalcitonin levels are more sensitive than serum CRP levels.The investigators aimed to assess its predictive value in terms of post-cesarean wound infection. The serum procalcitonin levels are aimed to measure in participants who had cesarean section and developed surgical site infection. The investigators aimed to compare the serum procalcitonin levels between the patients who need secondary suture and the patients who did not need secondary suture.

+Arms and interventions

ArmTypeInterventionsDescription
No secondary sutureOther: procalcitonin levelThe participants who developed post-cesarean surgical site infection and follow-up only antibiotic treatment for their wound care.
Secondary sutureOther: procalcitonin levelThe participants who developed post-cesarean surgical site infection and need a secondary suture for their wound care
  • procalcitonin level (Other): serum procalcitonin level will be measured in both groups.

+Outcome measures

Primary outcomes

  • Serum procalcitonin levels in participants who developed wound infection after cesarean sections [5 months]: Serum procalcitonin levels will be measured in participants who will develop post-cesarean wound site infections. The serum procalcitonin levels will be compared in subgroups who need secondary suture and those who don't require suturing

+Eligibility

Sex: Female, ages: 18 Years to 40 Years

Inclusion Criteria:

* who developed surgical site infection after their cesarean sections.
* 18-40 years old

Exclusion Criteria:

* history of chorioamnionitis and premature rupture of membranes
* urinary tract infections
* any infectious condition other than surgical site infection

+Locations (1)

FacilityCityCountryStatus
Kanuni SSRTHIstanbulTurkey (Türkiye)

+Publications

  • Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013 May;13(5):426-35. doi: 10.1016/S1473-3099(12)70323-7. Epub 2013 Feb 1. PMID 23375419
  • Takakura Y, Hinoi T, Egi H, Shimomura M, Adachi T, Saito Y, Tanimine N, Miguchi M, Ohdan H. Procalcitonin as a predictive marker for surgical site infection in elective colorectal cancer surgery. Langenbecks Arch Surg. 2013 Aug;398(6):833-9. doi: 10.1007/s00423-013-1095-0. Epub 2013 Jun 20. PMID 23784676
  • Results publication: Erenel H, Yilmaz N, Oncul M, Acikgoz AS, Karatas S, Ayhan I, Aslan B, Tuten A. Usefulness of Serum Procalcitonin Levels in Predicting Tubo-Ovarian Abscess in Patients with Acute Pelvic Inflammatory Disease. Gynecol Obstet Invest. 2017;82(3):262-266. doi: 10.1159/000449161. Epub 2016 Sep 3. PMID 27592364
  • Results publication: Aslan Cetin B, Aydogan Mathyk B, Koroglu N, Temel Yuksel I, Konal M, Erenel H, Atis Aydin A. Serum procalcitonin levels in incisional surgical site infections requiring a secondary suture after cesarean sections. J Matern Fetal Neonatal Med. 2019 Dec;32(24):4108-4113. doi: 10.1080/14767058.2018.1481949. Epub 2018 Jun 20. PMID 29804483

+Investigators

My Notes