Research on the Clinical Effect of Gualou Xiebai Banxia Decoction Compounded With Danshen Decoction in Treating Unstable Angina.
| Registry | NCT03179514 |
|---|---|
| Status | Unknown |
| Phase | Phase 4 |
| Study type | Interventional; randomized, parallel, masking: none, treatment |
| Enrollment | 120 (Estimated) |
| Sponsor | Jun Li (Other); collaborators: Guang'anmen Hospital of China Academy of Chinese Medical Sciences |
| Conditions | Unstable Angina |
| Interventions | Anti-Platelet Drugs, Lipid Regulating Drugs, Coronary Vasodilator, Gualou Xiebai Banxia Decoction & Danshen Decoction (Drug) |
| Dates | start 2017-07-01 (estimated), primary completion 2019-10-01 (estimated), completion 2019-12-01 (estimated), first posted 2017-06-07, last updated 2017-06-07 |
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This study evaluates the clinical efficacy of Gualou Xiebai Banxia Decoction compounded with Danshen Decoction in the treatment of unstable angina pectoris. All of the patients will be divided into 2 arms randomly. One of the arms will be treated by conventional western medicine, the other one will be treated by Gualou Xiebai Banxia Decoction compounded with Danshen Decoction at the base of conventional western medicine.
Gualou Xiebai Banxia Decoction compounded with Danshen Decoction has the effect of promoting blood circulation and resolving phlegm, so it will be used for patients taht belong to phlegm and blood stasis type.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Phlegm and blood stasis | Experimental | Drug: Anti-Platelet Drugs; Drug: Lipid Regulating Drugs; Drug: Coronary Vasodilator; Drug: Gualou Xiebai Banxia Decoction & Danshen Decoction | Patients in this group will be treated by Gualou Xiebai Banxia Decoction \& Danshen Decoction at the base of conventional western medicine. |
| Conventional western medicine | Other | Drug: Anti-Platelet Drugs; Drug: Lipid Regulating Drugs; Drug: Coronary Vasodilator | Patients in this group will be treated by conventional western medicine, including anti-platelet drugss，lipid regulating drugs, coronary vasodilator, etc. |
Sex: All, ages: 35 Years to 70 Years
Inclusion Criteria: * Participants diagnosed with coronary heart disease through coronary angiography or coronary CTA; Patients have at least one of these symptoms: 1. The stability of the nature of angina pectoris changes, that is, frequent attacks of angina pectoris, serious degree and prolonged duration; 2. Angina pectoris during rest; 3. The recent occurrence of angina pectoris caused by mild physical activity in the last month. Exclusion Criteria: * Patients diagnosed with stable angina; Patients with acute myocardial infarction; Chest pain caused by congenital heart disease, valvular heart disease, severe neurosis or arrhythmia; The heart function grade is III or IV; Patients with acute cerebral infarction; Patients complicated with other serious primary diseases; Patients with acute infection in recent 2 weeks; Uncontrolled hypertension (the resting blood pressure >160/95mmHg within one week); Diabetics emerged with serious diabetic complications; Patients can't finish the questionnaire due to abnormal mental and nervous or mental disorders; Pregnant or lactating women.