Understanding How Anaesthesia Affects ECT Outcomes

NCT03105245 — Phase 3, Completed, 54 participants, The University of New South Wales

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Registry	NCT03105245
Status	Completed
Phase	Phase 3
Study type	Interventional; randomized, crossover, masking: double, treatment
Enrollment	54 (Actual)
Sponsor	The University of New South Wales (Other); collaborators: Wesley Mission
Conditions	Depression
Interventions	Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone) (Other)
Dates	start 2017-03-15, primary completion 2019-03-15, completion 2019-03-15, first posted 2017-04-07, last updated 2023-03-30
Locations	1 site in Australia

-Summary

This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus, impacts on the quality of the EEG (this is a recording of brain activity during ECT and is used to judge the quality of a seizure and to guide individual patient dosing).

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+Detailed description

This study aims to examine how the time interval between administration of anaesthetic agent and ECT stimulus delivery impacts upon measures of EEG quality (seizure quality).

+Arms and interventions

Arm	Type	Interventions
Short time interval + Normal ventilation	Active comparator	Other: Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
Short time interval + Hyperventilation	Active comparator	Other: Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
Long time interval + Normal ventilation	Active comparator	Other: Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)
Long time interval + Hyperventilation	Active comparator	Other: Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)

Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone) (Other): The intervention in this study is the time interval between anaesthetic administration and ECT stimulus

+Outcome measures

Primary outcomes

EEG Seizure Quality Rating using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al [Outcome measures will be collected immediately after each ECT treatment from the first treatment until the end of the ECT course, an estimated total of four to six weeks for most participants]: EEG quality will be rated manually for each ECT treatment undertaken by a participant until the conclusion of their ECT course. This rating will be done using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al - low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy; Journal of Affective Disorders, 2010; 126: 330-333

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Patients treated with a course of ECT

Exclusion Criteria:

* Use of non-standard anaesthetic agents in ECT (e.g. ketamine)

+Locations (1)

Facility	City	Country	Status
Wesley Hospital Kogarah	Sydney, New South Wales	Australia

+Investigators

Colleen Loo, MBBS, Principal investigator, The University of New South Wales