Impact of Variable Types of Preconditioning Upon the Inotrope Score in Adult Patients, Undergoing Cardiac Surgery
| Registry | NCT03105089 |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, parallel, masking: double, prevention |
| Enrollment | 60 (Actual) |
| Sponsor | Assiut University (Other) |
| Conditions | Open Heart Surgery, Preconditioning |
| Interventions | ischemic preconditioning (Procedure) |
| Dates | start 2016-03-01, primary completion 2017-02-01, completion 2017-05-01, first posted 2017-04-07, last updated 2017-10-30 |
| Locations | 1 site in Egypt |
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preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support
Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ;pharmacologic or Physical) Pharmacological pc may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc ) Ischemic pc includes local ;remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs The liberated mediators have favorable effects not only upon the myocardium But ;it extend to protect other organs against inflammatory activation ;ischemia reperfusion injury Inotropic score IS is already an evident predictor of postoperative cardiac mobidity and mortality
| Arm | Type | Interventions | Description |
|---|---|---|---|
| ischemic preconditioning | Active comparator | Procedure: ischemic preconditioning | ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles |
| control | No intervention | no intervention will be done |
Sex: All, ages: 16 Years to 60 Years
Inclusion Criteria: * adult patient * valve replacement surgery * ASA grade 2 or 3 Exclusion Criteria: * emergency surgery * \- poor general conditions * impaired hepatic or renal function * peripheral vascular disease * patient refusal
| Facility | City | Country | Status |
|---|---|---|---|
| Emad Zarief Kamel Said | Asyut | Egypt |