Technical Development of Multi-Parametric Renocerebral MRI

NCT02831335 — Suspended, 120 participants, University of Minnesota

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Registry	NCT02831335
Status	Suspended - Due to funding issus
Study type	Observational
Enrollment	120 (Estimated)
Sponsor	University of Minnesota (Other)
Conditions	Aging
Interventions	MRI, Group 4 (Other)
Dates	start 2027-12-01 (estimated), primary completion 2030-12-31 (estimated), completion 2032-12-31 (estimated), first posted 2016-07-13, last updated 2026-10-14
Locations	1 site in United States

-Summary

The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

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+Arms and interventions

Arm	Interventions	Description
Group 1	Other: MRI	normal 21-35 years old participants
Group 2	Other: MRI	normal 36-50 years old participants
Group 3	Other: MRI	normal 51-65 years old participants
Group 4	Other: Group 4	normal 66- 80 years old participants

MRI (Other): Perform MRI studies
MRI (Other): Perform MRI studies
MRI (Other): Perform MRI studies
Group 4 (Other): Perform MRI studies

+Outcome measures

Primary outcomes

MRI measured perfusion for each group [Baseline]: MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
MRI measured vascular reactivity for each group [Baseline]: MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
Cognitive performance for each group [Baseline]: The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.

+Eligibility

Sex: All, ages: 21 Years to 80 Years, accepts healthy volunteers

Inclusion Criteria:

1. English-speaking as primary language
2. No hearing loss or uncorrected vision

Exclusion Criteria:

1. Lacking capacity to consent
2. Having known history of cardiovascular diseases (e.g., clinical stroke)
3. Having acute and chronic obstructive pulmonary disease
4. Having known history of renal diseases (e.g., acute kidney injury)
5. Having known history of cognitive disorder or psychiatric illness
6. Having known history of chemical dependence (e.g., alcohol and narcotics)
7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

+Locations (1)

Facility	City	Country	Status
Center for Magnetic Resonance Research	Minneapolis, Minnesota	United States

+Investigators

Xiufeng Li, Ph.D., Principal investigator, University of Minnesota