Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)

NCT02827734 — Unknown, 50 participants, Universitätsmedizin Mannheim
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RegistryNCT02827734
StatusUnknown
Study typeObservational
Enrollment50 (Estimated)
SponsorUniversitätsmedizin Mannheim (Other)
ConditionsPulmonary Healthy Controls, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Non-specific Interstitial Pneumonia, Sarcoidosis, Granulomatosis With Polyangiitis (Wegener's Disease)
Interventionsmultiple breath washout tests, impulse oscillometry, body plethysmography (Device)
Datesstart 2015-10-01, primary completion 2020-12-01 (estimated), completion 2020-12-01 (estimated), first posted 2016-07-11, last updated 2020-03-24
Locations1 site in Germany

Related Papers Related Patents Related Grants Related Experts
All trials for Pulmonary Healthy Controls All trials for Interstitial Lung Disease All trials of multiple breath washout tests All trials of impulse oscillometry

-Summary

Current diagnostic tools used in interstitial lung disease (ILD) do not meet the challenges set by the complex pathophysiology of this heterogenous group. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various ILDs.

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+Arms and interventions

ArmTypeInterventionsDescription
interstitial lung diseaseDevice: multiple breath washout tests; Device: impulse oscillometry; Device: body plethysmographypatients with known or suspected ILD such as idiopathic pulmonary fibrosis, non-specific interstitial pneumonia, sarcoidosis, granulomatosis with polyangiitis
pulmonary healthy controlsDevice: multiple breath washout tests; Device: impulse oscillometry; Device: body plethysmographypatients without known or suspected pulmonary disease
  • multiple breath washout tests (Device)
  • impulse oscillometry (Device)
  • body plethysmography (Device)

+Outcome measures

Primary outcomes

  • lung clearance index (LCI) as determined by multiple breath washout [30 minutes]
  • airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry [30 minutes]

Secondary outcomes

  • repeatability of lung clearance index (LCI) [30 minutes]

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* known or suspected interstitial lung disease

Exclusion Criteria:

* pregnancy
* inability to participate

+Locations (1)

FacilityCityCountryStatus
Universitätsmedizin MannheimMannheim, DeutschlandGermanyRecruiting