| Registry | NCT02813954 |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 184 (Actual) |
| Sponsor | Kanuni Sultan Suleyman Training and Research Hospital (Other) |
| Conditions | Respiratory Distress Syndrome, Transient Tachypnea of Newborn |
| Interventions | Blood Gas Sampling (Device) |
| Dates | start 2015-08-01, primary completion 2016-04-01, completion 2016-04-01, first posted 2016-06-27, last updated 2022-08-18 |
Related Papers Related Patents Related Grants Related Experts
All trials for Respiratory Distress Syndrome All trials for Transient Tachypnea of Newborn All trials of Blood Gas Sampling
Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress. While fetal urine is the major content of AF since 20th gestational week, fetal lung liquid (FLL) also acts as a minor content. Secretion of FLL depends on chloride transport and postnatal clearance of FLL is provided by active reabsorption of sodium (Na) ions. Down-regulation of epithelial Na channels (ENaCs) and an increase of pulmonary compliance accompany to pulmonary adaptation developing at the first hours of life. Lower genomic expression of Na channels in airways is shown to be associated to respiratory distress syndrome (RDS) in preterm. Although pH and electrolyte value of AF is thought to be relevant to fetal and maternal conditions such as gestational age, antenatal steroids and preterm birth, there is no study about this topic in the literature.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Study Group | Device: Blood Gas Sampling | Neonates with respiratory distress | |
| Control Group | Healthy Infants |
Sex: All, ages: any to 25 Hours, accepts healthy volunteers
Inclusion Criteria: Accepted to participate with informed consent Normal healthy pregnancies Exclusion Criteria: Congenital abnormalities Chromosomal abnormalities Blood contaminated AF Declined to participate