Metabolic Exercise Testing

NCT02362685 — Recruiting, 1000 participants, University Hospital, Brest

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Exercise Testing in Metabolic Myopathies

Registry	NCT02362685, acronym RANNOU
Status	Recruiting
Study type	Observational
Enrollment	1000 (Estimated)
Sponsor	University Hospital, Brest (Other)
Conditions	Metabolic Myopathies, Exercise Test, Myalgia
Interventions	functional test, matching genotype with phenotype (Device, genetic)
Dates	start 2008-09-01, primary completion 2027-12-01 (estimated), completion 2027-12-01 (estimated), first posted 2015-02-13, last updated 2020-01-22
Locations	1 site in France

-Summary

Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

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+Arms and interventions

Arm	Type	Interventions	Description
metabolic exercise testing		Device: functional test; Genetic: matching genotype with phenotype	All the subjects referred to performed a metabolic exercise testing.

functional test (Device): subjects perform a metabolic exercise testing
matching genotype with phenotype (Genetic)

+Outcome measures

Primary outcomes

Whole-body dynamic exercise [Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed]: The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Grip-test [Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed]: The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Blood tests [Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed]: The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.

+Eligibility

Sex: All, ages: 5 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
* Ability to provide informed consent

Exclusion Criteria:

* Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
* Pregnancy or unknown pregnancy status.

+Locations (1)

Facility	City	Country	Status
Centre Hospitalier Régional Universitaire	Brest	France	Recruiting

+Investigators

Fabrice Rannou, MD, PhD, Principal investigator, CHRU BREST