Endogenous DNA Transposition in Rhabdoid Tumors
| Registry | NCT01544569 |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 50 (Estimated) |
| Sponsor | Children's Oncology Group (Network); collaborators: National Cancer Institute (NCI) |
| Conditions | Kidney Cancer |
| Interventions | DNA analysis, fluorescence in situ hybridization, gene expression analysis, gene mapping, microarray analysis, polymerase chain reaction, protein expression analysis, laboratory biomarker analysis, medical chart review (Genetic, other) |
| Dates | start 2012-03-01, primary completion 2016-05-01, first posted 2012-03-06, last updated 2016-05-18 |
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RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.
PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.
OBJECTIVES:
* To investigate the expression and function of transposons in 50 primary rhabdoid tumors.
OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.
Sex: All, ages: any to 1 Year
DISEASE CHARACTERISTICS: * Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age * Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified