Genetics of Spina Bifida and Anencephaly

NCT00636233 — Completed, 10000 participants, Duke University

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The Hereditary Basis of Neural Tube Defects

Registry	NCT00636233
Status	Completed
Study type	Observational
Enrollment	10000 (Estimated)
Sponsor	Duke University (Other); collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Anencephaly, Acrania
Dates	start 1993-05-01, primary completion 2017-08-02, completion 2017-08-02, first posted 2008-03-14, last updated 2020-04-02
Locations	1 site in United States

-Summary

The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly. Ultimately, this type of research may result in improved diagnosis, improved treatment and possibly prevention.

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+Arms and interventions

Arm	Type	Interventions	Description
Anencephaly			Fetuses with anencephaly, parents and siblings

+Outcome measures

Primary outcomes

genetic factors associated with neural tube defects [end of the study]: This study aims to discover genetic factors associated with neural tube defects such as anencephaly.

+Eligibility

Sex: All

Not currently enrolling new participants.

+Locations (1)

Facility	City	Country	Status
Duke University Medical Center	Durham, North Carolina	United States

+Investigators

Allison Ashley-Koch, PhD, Principal investigator, Duke Health

+Funding

NIH grants: R01NS039818