Water and the Gastropressor Response - Tachyphylaxis

NCT00580996 — Not applicable, Active not recruiting, 20 participants, Satish R. Raj

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Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)

Registry	NCT00580996
Status	Active not recruiting
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: none, other
Enrollment	20 (Estimated)
Sponsor	Satish R. Raj (Other)
Conditions	Orthostatic Hypotension
Interventions	water high dose, water tiny dose (Other)
Dates	start 2006-07-01, primary completion 2029-12-01 (estimated), completion 2029-12-01 (estimated), first posted 2007-12-27, last updated 2026-10-16
Locations	1 site in United States

-Summary

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

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+Detailed description

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

+Arms and interventions

Arm	Type	Interventions	Description
1	Experimental	Other: water high dose	16 oz water in AM
2	Active comparator	Other: water tiny dose	water 1 oz in AM

water high dose (Other): water 16 oz PO x 1
water tiny dose (Other): water 1 oz PO x 1

+Outcome measures

Primary outcomes

blood pressure [2nd water intervention]

Secondary outcomes

heart rate [2nd intervention]

+Eligibility

Sex: All, ages: 18 Years to 80 Years

Inclusion Criteria:

* orthostatic hypotension (fall in BP>20/10 mmHg)
* pressor response to water in other studies
* Age 18-80 years

Exclusion Criteria:

* pregnancy

+Locations (1)

Facility	City	Country	Status
Vanderbilt University	Nashville, Tennessee	United States

+Investigators

Satish R Raj, MD MSCI, Principal investigator, Vanderbilt University Medical Center