Daily Bioengineering Papers

Highlight: By deconstructing the molecular logic of functional divergence and pharmacological targeting, we argue that a promising direction for precision microecological therapy may involve moving beyond broad taxonomic classification toward quantitative matching of strain-specific functional and enzymatic fingerprints.

Highlight: Here, we developed a multifunctional hydrogel platform (GO-EM/Ba) that integrates ultrasound-triggered wireless electrical stimulation with inflammatory modulation for SCI therapy.

Highlight: This study used a standardized 3D fluid-structure interaction model to simulate nine cases combining different transvalvular gradients and ascending aortic diameters, in order to analyze leaflet kinematics and hemodynamics.

Highlight: Stem cell-based therapies have emerged as promising strategies to restore bone regeneration, with investigations focusing on mesenchymal stromal cells, skeletal stem cells, adipose-derived stromal cells, induced pluripotent stem cell-derived osteogenic progenitors, and cell-free approaches such as extracellular vesicles and secretomes. This narrative review examines the biological mechanisms underlying bone aging, the impact of the aged microenvironment on stem-cell function, and current approaches to rejuvenate skeletal regeneration.

Highlight: Although current prevention largely depends on risk avoidance and systemic supportive measures, locally applied biomaterial systems specifically designed for irradiated extraction sockets are still lacking. This narrative review included 107 studies identified from 2094 records and analyzed emerging biomaterial approaches in relation to the pathological barriers to socket healing after radiotherapy.

Highlight: Thus, the developed nanocomposites are promising, and the investigation presents a cost-effective and scalable approach to tailoring the mechanical, degradation, and biocompatibility of biodegradable biomaterials.

Highlight: Here, we present an electric field-driven approach to rapidly fabricate a biomimetic conductive hydrogel featuring simultaneous gradients in stiffness, conductivity, and morphology.

Highlight: Here, we investigated an on-demand strategy for the intraoperative fabrication of antiadhesion barriers using polyurethane dispersion (PUD) and poly(ethylene oxide) (PEO) nanofiber (NF) mats fabricated by a handheld electrospinning device.