Anesthesia Papers of the Week

Methods: We conducted a randomized, open-label, noninferiority trial at a tertiary pediatric orthopaedic hospital.

While preclinical studies point to sex-specific development of tolerance, this has not been translated to humans. In this randomized, double-blind, placebo-controlled crossover study, 44 participants (22 F) smoked three cannabis strengths (0% [~0 mg] THC, 4% [~20 mg] THC, 10% [~60 mg] THC), provided blood for plasma analysis, and completed subjective mood and drug effects assessments and a self-administration task.

Thus, providing adequate organ perfusion while preventing fluid overload remains a major challenge in perioperative care. Here we describe a precision-based resuscitation strategy incorporating advanced imaging modalities, such as tissue Doppler and speckle-tracking echocardiography, and tailored volume management to preserve hemodynamic equilibrium and improve outcomes in this high-risk cohort.

This review synthesises evidence on opioid pharmacology, clinical applications, adverse effects, and opiophobia. This structured narrative review followed the SANRA criteria; PRISMA and PRISMA-ScR frameworks were not applied.

We conducted a posttest-only study comparing families of children with CLM.

Independent validation cohorts were used as the unit of analysis, and sensitivity and specificity were pooled using a bivariate random-effects model.

Remimazolam is an ultra-short-acting benzodiazepine that undergoes rapid carboxylesterase-mediated hydrolysis and can be antagonised with flumazenil. This narrative review examines its pharmacology, clinical evidence, and practical use across nine vulnerable populations.

This study evaluated the impact of positive sonication in MSIS-negative, culture-negative patients.

We determined whether dexmedetomidine- and esketamine-based opioid-free anesthesia (OFA) was non-inferior to opioid-based anesthesia (OA) for 24-hour Quality of Recovery-15 (QoR-15) after elective knee arthroscopy with femoral nerve block.

In some patients, nociceptive output persists after the initial lesion has stabilized. This Mini Review examines whether a durable senescence-like state in dorsal root ganglion (DRG) sensory neurons may contribute to failed pain resolution.

Stellate ganglion block (SGB), an interventional technique that modulates sympathetic activity, has been increasingly investigated beyond traditional pain management in cardiology, neuropsychiatry, and perioperative medicine. This narrative review examines the evolving role of SGB in contemporary anesthesia practice, emphasizing that its effects may extend beyond immediate peripheral sympatholysis to longer-lasting central neural modulation.

While two-stage arthroplasty (TSA) is the current standard of care, single-stage arthroplasty (SSA) may offer distinct advantages. This study compared infection control, functional recovery, hospital stay, costs, and complications between TSA and SSA in this patient population.