Biophysics Papers of the Week

We performed transcriptome mining and functional screening of candidate genes fromI.

This review integrates the existing evidence on the regulation of tumor metabolism and immune microenvironment by ECM mechanical signals, focuses on summarizing the key mechanical sensing pathways, feedback mechanisms, and therapeutic targets, and proposes research directions for precisely identifying key regulatory nodes of the mechanical-metabolic axis by combining spatial omics, metabolic flux analysis, and mechanical imaging techniques, providing a conceptual framework for developing novel therapeutic strategies targeting the biomechanical processes of tumors.

An integrated network pharmacology and transcriptomic approach was used to identify ferroptosis-related candidate targets of A. annua.

Aflatoxin B1 (AFB1) is a widespread food contaminant and environmental health concern, but the intestinal signaling events that may precede systemic toxicity remain insufficiently characterized. We hypothesized that AFB1 disrupts intestinal barrier organization through a PDGFRA-associated PI3K-Akt-mTOR signaling response, and we tested this hypothesis by integrating network toxicology, RNA sequencing, molecular docking, molecular dynamics simulations, and experimental models.

This review highlights thermochemical conversion pathways, chemical interactions, molecular dynamics simulations, and optimization strategies to enhance the performance of bio-asphalt.

This review provides a systematic overview of 125 newly identified neuroprotective natural products derived from plants, microorganisms, and marine organisms in 2025, with a comprehensive summary of their origins, chemical architectures, and biological activities.

Myeloid cell leukemia-1 (Mcl-1) is a key anti-apoptotic protein that drives resistance to chemotherapy, making it a critical oncology target. In this study, we synthesized a new indenonaphthodiazepine[5.3.3]propellane a one-pot multicomponent reaction and characterized its structure by FT-IR, H-NMR, C-NMR, and mass spectrometry.

This study aimed to investigate the molecular mechanisms through which PPT regulated NLRP3 inflammasome activation and mediated anti-inflammatory effects in mice. We employed limited proteolysis-mass spectrometry to identify NLRP3 as a direct target of PPT, and validated this interaction using cellular thermal shift assay, site-directed mutagenesis, co-immunoprecipitation, and surface plasmon resonance.

Here, we introduce Live Spatial Transcriptomics (Live-ST), a technology that enables longitudinal, transcriptome-wide profiling of living tissue.

Here, we present a systematic methodology for automated construction of reactive MLIPs using SPARC, an open-source workflow package that integrates AL with enhanced sampling through the PLUMED library.

In this review, recent advances in LM-enabled energy storage are summarized from the perspectives of physicochemical properties, micro-/macroscopic structural regulations, and performance-oriented applications.

In this study, bovine testicular hyaluronidase (BTH) was selected as the target enzyme.

Because the study used reporter constructs, a lipophilic dye, pseudovirus and mice, it does not establish intact-LNP biodistribution or protection against authentic SARS-CoV-2 infection.

This study investigates the role of circulating human serum peptides (HSPs) in modulating protein association on densely PEGylated NPs.

Here we show that the N-terminal helix (αN) of Gα promotes GDP release through a rotational conformational change.