6 completed, 1 not yet recruiting. 4 Phase 1, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow zoliflodacin: new trials by email Literature Review of zoliflodacin trials Research Report on zoliflodacin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Effect of a Single Oral Dose of Zoliflodacin 3 g on Testicular Function in Healthy Adult Men Zoliflodacin, Placebo - Testicular Abnominalies | Phase 4 | Not yet recruiting | Global Antibiotics Research and Development Partnership | 200 | 2026-10-01 | 2026-06-10 |
| Zoliflodacin in Uncomplicated Gonorrhoea zoliflodacin, ceftriaxone, azithromycin - Gonorrhea | Phase 3 | Completed | Global Antibiotics Research and Development Partnership | 1011 | 2019-11-06 | 2025-10-08 |
| Study to Investigate Effect of Food and Safety of a New Formulation of Zoliflodacin Zoliflodacin, high calorie, high fat breakfast - Gonorrhea | Phase 1 | Completed | Drugs for Neglected Diseases | 48 | 2018-10-03 | 2018-12-06 |
| Thorough QT/QTC (TQT) Clinical Trial to Evaluate the Effect of Zoliflodacin on Cardiac Repolarization in Healthy Male and Female Subjects AZD0914, Moxifloxacin, Placebo - Electrocardiogram Repolarisation Abnormality, Gonococcal Infection | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 72 | 2018-09-25 | 2020-03-27 |
| A Study to Evaluate the Safety, Tolerability and Plasma PK of a Single Oral Dose of Zoliflodacin in Healthy Male and Female Volunteers AZD0914 - Gonorrhoea | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 8 | 2018-02-02 | 2019-03-18 |
| AZD0914 Phase 1 ADME Study in Healthy Volunteers AZD0914 - Healthy | Phase 1 | Completed | Entasis Therapeutics | 6 | 2015-01-01 | 2015-06-03 |
| Randomized, Open-label Phase 2 Study of Oral AZD0914 in the Treatment of Gonorrhea AZD0914, Ceftriaxone - Gonorrhoea | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 180 | 2014-11-25 | 2017-03-22 |
Gonorrhea (5) · Sexually Transmitted Diseases (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · Global Antibiotics Research and Development Partnership (2) · Drugs for Neglected Diseases (1) · Entasis Therapeutics (1)
United States (6) · Belgium (1) · Germany (1) · Netherlands (1) · South Africa (1) · Thailand (1) · United Kingdom (1)
Irene Mirkin, MD (1) · Juan Perez-Morales, MD (1)
PMID 30373802, PMID 30403954, PMID 34606332, PMID 38130409, PMID 41391465
2019 (1)