10 completed, 1 terminated, 1 withdrawn. 5 Phase 2, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Withdrawn 1 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
Follow vaniprevir: new trials by email Literature Review of vaniprevir trials Research Report on vaniprevir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Fine Needle Aspiration to Measure Hepatic Vaniprevir (MK-7009) Concentrations in Participants With Chronic Hepatitis C (MK-7009-048) Vaniprevir 600 mg, Peg-IFN alfa-2b, Ribavirin - Chronic Hepatitis C | Phase 1 | Completed | Merck Sharp & Dohme LLC | 31 | 2012-10-30 | 2022-08-26 |
| Vaniprevir Plus PegIntron®/Ribavirin in Japanese Participants With Chronic Hepatitis C Who Are Non-responders to Previous Treatment (MK-7009-045) Vaniprevir, peg-IFN, ribavirin - Hepatitis C, Chronic | Phase 3 | Completed | Merck Sharp & Dohme LLC | 42 | 2011-09-02 | 2018-10-18 |
| Study of Vaniprevir Plus PegIntron®/Ribavirin in Japanese Participants With Chronic Hepatitis C Who Relapsed After Treatment (MK-7009-044) vaniprevir, peg-IFN, ribavirin - Hepatitis C, Chronic | Phase 3 | Completed | Merck Sharp & Dohme LLC | 51 | 2011-08-29 | 2018-10-18 |
| Vaniprevir Administered With Pegylated-interferon and Ribavirin in Japanese Treatment-Naïve Chronic Hepatitis C Participants (MK-7009-043) vaniprevir, Placebo to vaniprevir, Peg-IFN - Hepatitis C, Chronic | Phase 3 | Completed | Merck Sharp & Dohme LLC | 294 | 2011-06-27 | 2018-10-18 |
| Study to Evaluate Different Regimens of Vaniprevir (MK7009) for the Treatment of Chronic Genotype 1 Hepatitis C Virus Infection in Treatment-naive Patients (MK-7009-019)(WITHDRAWN) vaniprevir (MK7009), Comparator: vaniprevir (MK7009), Comparator: Pegylated Interferon (peg-IFN) alfa-2a - Chronic Genotype 1 Hepatitis C Virus Infection | Phase 2 | Withdrawn | Merck Sharp & Dohme LLC | 2010-11-01 | 2015-10-22 | |
| Pharmacokinetics of Vaniprevir (MK-7009) and Hepatitis C Virus RNA Levels After Vaniprevir Treatment (MK-7009-029) Vaniprevir - Chronic Hepatitis C Infection | Phase 1 | Terminated | Merck Sharp & Dohme LLC | 3 | 2010-01-13 | 2018-10-18 |
| A Study of Vaniprevir (MK-7009) in Participants With Chronic Hepatitis C Infection After Participation in Other Vaniprevir Studies (MK-7009-028) Vaniprevir 600 mg b.i.d., Vaniprevir 300 mg b.i.d., Pegylated interferon - Hepatitis C, Chronic | Phase 2 | Completed | Merck Sharp & Dohme LLC | 45 | 2009-10-23 | 2021-02-08 |
| A Study Investigating the Influence of Hepatic Insufficiency on the Pharmacokinetics of Vaniprevir (MK-7009-005) Vaniprevir 300 mg, Vaniprevir 200 mg - Hepatitis C | Phase 1 | Completed | Merck Sharp & Dohme LLC | 60 | 2009-07-01 | 2018-10-09 |
| A Study of Safety and Efficacy of Vaniprevir Administered With Pegylated-Interferon and Ribavirin in Japanese Participants With Chronic Hepatitis C Infection (7009-016) Vaniprevir, Pegylated Interferon (peg-IFN), Ribavirin - Hepatitis C | Phase 2 | Completed | Merck Sharp & Dohme LLC | 90 | 2009-04-20 | 2018-10-09 |
| Safety and Efficacy of Vaniprevir (MK-7009) With Pegylated Interferon (Peg-IFN) and Ribavirin (RBV) in Treatment-Experienced Hepatitis C Virus (HCV) Participants (MK-7009-009) Vaniprevir, Pegylated Interferon (Peg-IFN), Ribavirin (RBV) - Hepatitis C, Chronic | Phase 2 | Completed | Merck Sharp & Dohme LLC | 285 | 2009-03-27 | 2018-10-09 |
| Safety and Efficacy of Vaniprevir (MK7009) Administered With Pegylated-Interferon and Ribavirin (MK-7009-007) Comparator: Vaniprevir, Comparator: Pegylated-Interferon (Peg-IFN), Comparator: Ribavirin - Hepatitis C | Phase 2 | Completed | Merck Sharp & Dohme LLC | 95 | 2008-07-25 | 2018-10-09 |
| Study the Safety and Effectiveness of MK7009 in Hepatitis C Infected Patients (MK-7009-004)(COMPLETED) Comparator: MK7009, Comparator: Placebo - Hepatitis C | Phase 1 | Completed | Merck Sharp & Dohme LLC | 40 | 2007-07-01 | 2015-08-25 |
Hepatitis C (7) · Hepatitis C, Chronic (6)
PMID 26947564, PMID 23747481, PMID 26936417, PMID 22473713, PMID 23439259, PMID 24120953, PMID 25115901, PMID 26403160, PMID 31868916
2009 (2)