10 completed, 2 enrolling by invitation, 1 active not recruiting, 1 available. 9 Phase 3, 5 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 5, Active not recruiting 1, Enrolling by invitation 1, Recruiting 1, Terminated 1 |
| Phase 2 | 5 | Completed 4, Enrolling by invitation 1 |
| Phase 1 | 2 | Completed 2 |
Follow Tradipitant: new trials by email Literature Review of Tradipitant trials Research Report on Tradipitant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use Tradipitant, Placebo - Nausea and Vomiting, Obesity | Phase 3 | Recruiting | Vanda Pharmaceuticals | 280 | 2026-03-27 | 2026-04-20 |
| A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use Tradipitant, Placebo - Obesity | Phase 2 | Completed | Vanda Pharmaceuticals | 124 | 2025-02-25 | 2025-11-12 |
| Open Label Safety Study of Tradipitant in Idiopathic and Diabetic Gastroparesis Tradipitant - Idiopathic Gastroparesis, Diabetic Gastroparesis | Phase 3 | Completed | Vanda Pharmaceuticals | 17 | 2024-01-09 | 2026-10-19 |
| Motion Serifos: A Study to Investigate the Efficacy of Tradipitant in Participants Affected by Motion Sickness Tradipitant, Placebo - Motion Sickness | Phase 3 | Completed | Vanda Pharmaceuticals | 316 | 2023-09-09 | 2025-04-04 |
| Motion Delos: An Open Label Safety and Efficacy of Tradipitant in Participants Affected by Motion Sickness Tradipitant - Motion Sickness | Phase 3 | Active not recruiting | Vanda Pharmaceuticals | 705 | 2023-02-27 | 2026-04-16 |
| Tradipitant for Functional Dyspepsia Tradipitant, Placebo - Functional Dyspepsia | Phase 2 | Enrolling by invitation | Xiao Jing (Iris) Wang | 60 | 2023-02-09 | 2026-07-16 |
| Motion Syros: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness Tradipitant, Placebo - Motion Sickness | Phase 3 | Completed | Vanda Pharmaceuticals | 366 | 2021-11-15 | 2024-12-11 |
| Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers Tradipitant, Placebo - Healthy Volunteer | Phase 1 / Phase 2 | Completed | Vanda Pharmaceuticals | 27 | 2021-02-01 | 2024-04-16 |
| ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection Tradipitant, Placebo - Coronavirus Infection | Phase 3 | Enrolling by invitation | Vanda Pharmaceuticals | 300 | 2020-04-13 | 2020-04-20 |
| Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2) Tradipitant, Placebo - Atopic Dermatitis | Phase 3 | Terminated | Vanda Pharmaceuticals | 87 | 2019-10-21 | 2024-05-14 |
| Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis Tradipitant, Placebo, Open Label Tradipitant - Idiopathic Gastroparesis, Diabetic Gastroparesis | Phase 3 | Completed | Vanda Pharmaceuticals | 979 | 2019-08-20 | 2026-09-24 |
| Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness Tradipitant, Placebo - Motion Sickness | Phase 2 | Completed | Vanda Pharmaceuticals | 126 | 2018-12-20 | 2025-05-09 |
| Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE) Tradipitant, Placebo - Atopic Dermatitis | Phase 3 | Completed | Vanda Pharmaceuticals | 375 | 2018-07-09 | 2024-05-13 |
| Tradipitant in Treatment-resistant Pruritus Associated With Atopic Dermatitis Tradipitant, Placebo - Atopic Dermatitis | Phase 2 | Completed | Vanda Pharmaceuticals | 168 | 2016-01-19 | 2024-06-13 |
| Study to Assess the Effect of Multiple Doses of Tradipitant on CYP3A4 Using Midazolam as a Substrate in Healthy Subjects tradipitant, Midazolam - Healthy Volunteers | Phase 1 | Completed | Vanda Pharmaceuticals | 24 | 2015-11-01 | 2016-04-27 |
| Single-Patient Expanded Access Protocol for Tradipitant In A Single Patient With Gastroparesis Tradipitant - Gastroparesis, Diabetic Gastroparesis | Available | Vanda Pharmaceuticals | 2025-08-24 |
Nausea (5) · Vomiting (5) · Motion Sickness (4) · Dermatitis, Atopic (3) · Eczema (3) · Gastroparesis (3) · Obesity (2) · Coronavirus Infections (1)
Vanda Pharmaceuticals (15) · Xiao Jing (Iris) Wang (1)
United States (14) · Belgium (1) · Germany (1) · Switzerland (1)
PMID 42150111, PMID 34353696, PMID 35644931, PMID 38237696, PMID 40103934