2 unknown, 1 active not recruiting, 1 completed. 2 Not applicable, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Active not recruiting 1, Unknown 1 |
| Phase 2 | 1 | Unknown 1 |
Follow rAAV2-ND4: new trials by email Literature Review of rAAV2-ND4 trials Research Report on rAAV2-ND4
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation rAAV2-ND4, Sham (No Treatment) - Leber Hereditary Optic Neuropathy (LHON) | Phase 3 | Active not recruiting | Wuhan Neurophth Biotechnology Limited Company | 95 | 2024-09-19 | 2026-02-12 |
| Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months rAAV2-ND4 - Acute LHON, Onset Within Three Months | Not applicable | Unknown | Bin Li | 120 | 2018-01-08 | 2020-07-29 |
| A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy rAAV2-ND4 - Leber Hereditary Optic Neuropathy | Phase 2 / Phase 3 | Unknown | Huazhong University of Science and Technology | 159 | 2017-12-27 | 2020-09-17 |
| Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON) rAAV2-ND4 - Leber Hereditary Optic Neuropathy | Not applicable | Completed | Bin Li | 9 | 2011-04-01 | 2018-01-31 |
Optic Atrophy, Hereditary, Leber (3)
Bin Li (2) · Huazhong University of Science and Technology (1) · Wuhan Neurophth Biotechnology Limited Company (1)
China (4)
Bin Li, PhD,MD (1) · Yong Zhang, PhD,MD (1) · bin Li, PhD,MD (1)
PMID 26892229, PMID 30878986, PMID 1463007, PMID 1674640, PMID 18441370, PMID 18441371, PMID 18774912, PMID 1928099, PMID 22612072, PMID 22644094, PMID 23063736, PMID 24396955, PMID 25950380, PMID 26606867, PMID 27386292, PMID 27426279, PMID 27749593, PMID 31237206, PMID 3201231, PMID 5063796