2 completed, 2 not yet recruiting, 1 recruiting. 5 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 2, Not yet recruiting 2, Recruiting 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
Follow PfSPZ Challenge (NF54): new trials by email Literature Review of PfSPZ Challenge (NF54) trials Research Report on PfSPZ Challenge (NF54)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Malaria CVD 36000; Gates INV090205 PfSPZ Challenge (NF54), Wearable Biosensor Devices, Placebo - Malaria (Plasmodium Falciparum) | Phase 1 | Not yet recruiting | University of Maryland, Baltimore | 32 | 2026-11-01 | 2026-09-09 |
| Safety, Tolerability and Efficacy of PfSPZ-LARC2 Vaccine Against CHMI in Malaria-Naïve Adults Normal Saline (Placebo), PfSPZ-LARC2 Vaccine, PfSPZ Challenge (NF54) - Malaria Falciparum | Phase 1 | Recruiting | Sanaria Inc. | 58 | 2026-03-12 | 2026-06-22 |
| Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults Pyronaridine Tetraphosphate, Artesunate Drug Combination, PfSPZ Challenge (NF54), MVA ME-TRAP - Malaria | Phase 1 / Phase 2 | Not yet recruiting | University Hospital Tuebingen | 30 | 2025-06-01 | 2024-12-06 |
| Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis atovaquone/proguanil 250mg/100mg (A/P), PfSPZ Challenge (NF54), NaCl 0,9% - Malaria | Phase 1 | Completed | University Hospital Tuebingen | 30 | 2016-11-28 | 2019-07-15 |
| Sequential Optimization of Dose and Schedule of PfSPZ Vaccine PfSPZ Vaccine, PfSPZ Challenge (NF54), PfSPZ Challenge (7G8) - Malaria | Phase 1 | Completed | Sanaria Inc. | 45 | 2016-08-29 | 2019-02-01 |
Malaria (4) · Malaria, Falciparum (3)
Sanaria Inc. (2) · University Hospital Tuebingen (2) · University of Maryland, Baltimore (1)
Germany (2) · United States (1)
Peter G Kremsner, Prof (1) · Peter Kremsner, MD (1)
2015 (1)