5 completed, 2 terminated. 6 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 4, Terminated 2 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
Follow DSM265: new trials by email Literature Review of DSM265 trials Research Report on DSM265
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Malaria: Relative Bioavailability and Food Effect of DSM265 DSM265-TPGS 34% SDD, 400 mg fasted, DSM265-TPGS 34% SDD, 400 mg fed, DSM265 25% SDD, 400 mg fasted - Healthy Volunteers | Phase 1 | Completed | Medicines for Malaria Venture | 42 | 2018-10-03 | 2020-03-11 |
| Bioavailability and Effect of Food on DSM265 Granules in Healthy Adult Subjects DSM265 50% SDD granules, DSM265 25% SDD powder for suspension - Healthy Volunteers, Bioavailability | Phase 1 | Terminated | Medicines for Malaria Venture | 11 | 2016-05-01 | 2016-09-14 |
| DSM265 Prophylaxis of Plasmodium Falciparum Malaria DSM265, Placebo, Sporozoites - Healthy | Phase 1 | Completed | Medicines for Malaria Venture | 24 | 2016-03-01 | 2022-01-14 |
| DSM265 Phase IIa Investigation Treating Plasmodium Falciparum or Vivax DSM265 400mg, DSM265 xmg, DSM265 ymg - Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria | Phase 2 | Completed | Medicines for Malaria Venture | 45 | 2016-01-01 | 2016-06-22 |
| DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria DSM265 400mg, Placebo to DSM265 400 mg, Plasmodium falciparum sporozoite challenge - Plasmodium Falciparum, Malaria | Phase 1 | Completed | Medicines for Malaria Venture | 22 | 2015-10-01 | 2021-01-13 |
| A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection DSM265, OZ439 - Malaria | Phase 1 / Phase 2 | Terminated | Medicines for Malaria Venture | 16 | 2015-10-01 | 2020-06-05 |
| A Phase Ib Induced Malaria Infection Study With the Combination of OZ439 and DSM265 DSM265, OZ439 - Malaria | Phase 1 / Phase 2 | Completed | Medicines for Malaria Venture | 13 | 2015-02-01 | 2015-10-07 |
Malaria (5) · Malaria, Falciparum (2) · Infections (1) · Malaria, Vivax (1)
Medicines for Malaria Venture (7)
United States (3) · Australia (2) · Germany (1) · Peru (1)
James McCarthy, Prof (2) · Alejandro Llanos, Professor (1) · David Carter, MD (1) · James G Kublin, MD/MPH (1) · Joerg Moehrle, Ass Prof (1)
PMID 34179977, PMID 28363637, PMID 29909069, PMID 30858218, PMID 31685476, PMID 32479608